From:
Sukie Crandall
Date: 2007-05-03 18:42:01 UTC
Subject: [ferrethealth] Amyloidosis in BFFs
To: ferrethealth@yahoogroups.com
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J Zoo Wildl Med. 2007 Mar;38(1):32-41.
Links
Amyloidosis in the black-footed ferret (Mustela nigripes).
Garner MM, Raymond JT, O'Brien TD, Nordhausen RW, Russell WC.
Northwest ZooPath, Monroe, Washington 98272, USA.
This study describes clinical, histologic, immunohistochemical and
electron microscopic features of amyloid A amyloidosis occurring in
black-footed ferrets (Mustela nigripes) from eight U.S. zoological
institutions. Ferrets had nonregenerative anemia, serum chemistries
consistent with chronic renal disease, and proteinuria. Amyloid was
present in a variety of tissues, but it was most severe in renal
glomeruli
and associated with tubular protein loss and emaciation. Congo
red/potassium permanganate (KMnO4) and immunohistochemical stains
revealed that the amyloid was of the AA type. Concurrent diseases and
genetic predisposition were considered the most important contributing
factors to development of amyloidosis. Analysis of the genetic tree did
not reveal convincing evidence of a common ancestor in the affected
ferrets, but a genetic predisposition is likely because all the captive
black-footed ferrets are related.
PMID: 17469273 [PubMed - in process]
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Here is general info on amyloid A amyloidosis:
http://nmnf.epfl.ch/page9110.html
including
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It is believed that persistently high levels of SAA [blood serum
levels of
amyloid A] during chronic inflammation may contribute to the occasional
development of the potentially fatal disease reactive amyloidosis
(amyloid A (AA) amyloidosis). In AA amyloidosis, AA, an N-terminal
(1-76)
fragment of SAA, frequently is found to form amyloid deposits in the
liver,
kidney, and spleen.
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Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
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