From:
"Sukie Crandall"
Date: 2007-02-06 21:00:48 UTC
Subject: [ferrethealth] Re: mammary gland tumor and Doxorubicin
To: ferrethealth@yahoogroups.com
You probably should give strong thought to removing
the adrenal component from the equation by preferably
removing diseases adrenal(s) (and if both come out cleanly
or one is atrophied and remains then supply Percortin and
Prednisolone, or Fludrocort and Prednisolone to avoid a
fatal Addison Crisis), but if you can't then thoroughly
treating them (like with Lupron and melatonin if there is not
a medical conflict).
http://ferrethealth.org/archive/YPG312
BEGIN QUOTE
Yes, ferrets can develop mammary tumors.
They are rare because most female ferrets
are spayed. However adrenal gland disease
overproduces the same sex hormones that can
cause mammary cancer. Time to remove the adrenal
gland or glands if he is stable enough for surgery
or add Lupron depot to his adrenal treatment if he
is not stable enough for surgery.
Hope that helps,
Jerry Murray, DVM
END QUOTE
and from 2001:
http://ferrethealth.org/archive/YG4682
BEGIN QUOTE
Mammary hyperplasia (or for that matter, mammary tumors) are very
uncommon in domestic ferrets - but interestingly, very common in
black-footed ferrets, but that's a whole different subject.
However, in 50% of the 4 cases of mammary hyperplasia I have seen in
ferrets, the animals had concomitant adrenal tumors. While this
finding may simply be coincidental, the possibility that the mammary
hyperplasia is a direct result of excessive
estrogen/hydroxyprogesterone liberation from an adrenal lesion cannot
be ignored. The relative infrequence of it, couple with the
ubiquitousness of adrenal disease, though, ceratinly makes one think
that there may be another trigger involved in this process.
It would be interesting to see if the mammary lesion regressed if the
adrenal problem is addressed.
With kindest regards,
Bruce Williams, DVM
END QUOTE
http://ferrethealth.org/archive/YPG970
BEGIN QUOTE
Yes, either the oral melatonin at 1 to 3 mg
once a day or the melatonin implants will help
with doxorubicin chemotherapy. Plus melatonin
will help as an appetite stimulant and antioxidant.
[Looks like I missed typed the first post. Obviously
doxorubicin will suppress the appetite and is not an
antioxidant. Sorry about that mistake.]
Jerry Murray, DVM
END QUOTE
Parts of these ferret expert vets' comments could also
help you and your vets but you may need to get through
to the ends of some to find what you need and DO
NOTICE THE DATES since things change over time and
the FHL has been around for 6 years:
http://ferrethealth.org/archive/YPG105
http://ferrethealth.org/archive/SG7005
http://ferrethealth.org/archive/SG6389
http://ferrethealth.org/archive/SG468
http://ferrethealth.org/archive/SG448
http://ferrethealth.org/archive/YG9111
http://ferrethealth.org/archive/YG4477
http://ferrethealth.org/archive/SG11867
http://ferrethealth.org/archive/SG6831
Something to avoid:
http://ferrethealth.org/archive/YG4631
Putting
doxorubicin ferret
into search
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi
pulls up 17 journal articles
Sukie (not a vet)
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