From:
"Sukie Crandall"
Date: 2007-02-07 23:12:45 UTC
Subject: [ferrethealth] Re: Metranidazole injection?
To: ferrethealth@yahoogroups.com
--- In ferrethealth@yahoogroups.com, "janarickel@..." <janarickel@...> wrote:
>
> The vet I used to work for had metronidazole compounded into a
> topical preparation that owners could apply to the ferret's ears.
>
> Jana
>
http://ferrethealth.org/archive/YG8985
Says:
BEGIN QUOTE
I have serious concerns about the use of transdermal Flagyl. I have
discussed this with other vets on this list, as well as pharmacists.
Metronidazole is used in ferrets for treatment of two agents - one a
bacterium (Helicobacter) and one a protozoan (Giardia). Both of these
agents are extracellular and live in the lumen of the stomach and
intestine, respectively.
As these agents live outside the tissues of the body, in the space
within the gut, we rely on oral administration to get the proper
dosage of the antibiotic to these pathogens. When you administer it
with a cream, you get a low blood level of the antibiotic, which
likely does not get into the lumen of the gut at all, and is probably
of no effect.
Metronidazole creams are effective in human females for vaginal
infections, in which it is deposited into the vagina where it can be
effective against some pathogens, but is not used in that form for GI
problems.
With kindest regards,
Bruce Williams, DVM
END QUOTE
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