From:
"Sukie Crandall"
Date: 2007-01-02 16:19:00 UTC
Subject: [ferrethealth] abstract: DIM
To: ferrethealth@yahoogroups.com
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17197621&query_hl=1&itool=
pubmed_docsum>
BEGIN QUOTE
Vet Pathol. 2007 Jan;44(1):25-38.
Myofasciitis in the Domestic Ferret.
Garner MM,
Ramsell K,
Schoemaker NJ,
Sidor IF,
Nordhausen RW,
Bolin S,
Evermann JF,
Kiupel M.
654 West Main, Monroe, WA 98272. zoopath@aol.com.
Since late 2003, an inflammatory disease of muscle and
fascia has been diagnosed in several ferrets at Northwest
ZooPath, and this report describes the condition in 17
ferrets. It is a disease of young ferrets, characterized by
rapid onset of clinical signs, high fever, neutrophilic
leukocytosis, treatment failure, and death (or euthanasia).
Gross lesions include atrophy of skeletal muscle; red and
white mottling and dilatation of the esophagus; and
splenomegaly. Histologically, moderate to severe
suppurative to pyogranulomatous inflammation is in the
skeletal muscle and the fascia at multiple sites, including
esophagus, heart, limbs, body wall, head, and lumbar
regions. Myeloid hyperplasia of spleen and/or bone marrow
also is a prominent feature. Ultrastructural lesions include
mitochondrial swelling, intracellular edema, disruption of
myofibrils and Z bands. Bacterial and viral cultures, electron
microscopy, immunohistochemistry, and polymerase chain
reaction were negative for a variety of infectious agents. The
clinical presentation and distribution of lesions suggests that
polymyositis in domestic ferrets is likely a distinct entity. The
etiopathogenesis if this condition is not known.
PMID: 17197621 [PubMed - as supplied by publisher]
END QUOTE
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