From:
Sukie Crandall
Date: 2008-01-10 06:22:22 UTC
Subject: [ferrethealth] abstracts
To: ferrethealth@yahoogroups.com
J Vet Med Sci. 2007 Dec;69(12):1321-4.
Isolation and Chemiluminescent Properties of Ferret (Mustela putorius
furo) Polymorphonuclear Cells.
Nakata M, Itou T, Sakai T.
Nihon University Veterinary Research Center.
Ferret polymorphonuclear cells (PMNs) and peripheral blood mononuclear
cells (PBMCs) were separated from whole blood by density gradient
centrifugation. Using a 50% Percoll solution (density=1.066), PMNs and
PBMCs were successfully isolated after centrifugation; the purities of
the PMNs and PBMCs were 94.2% and 95.6%, respectively. To evaluate the
function of isolated ferret PMNs, we measured the superoxide
generation with a MCLA-dependent chemiluminescence assay. The isolated
ferret PMNs responded to phorbol 12-myristate 13-acetate (PMA) with
kinetics similar to that of human PMNs. The ferret PMNs did not
respond to N-formyl-Met-Leu-Phe (fMLF), unlike human PMNs, which
rapidly responded. Thus, authors established a method for the rapid
separation of highly purified populations of functional PMNs from the
whole blood of ferrets.
PMID: 18176035 [PubMed - in process]
END QUOTE
Article: http://www.jstage.jst.go.jp/article/jvms/69/12/1321/_pdf
Potential relevance:
BEGIN QUOTED SEGMENTS:
... few
reports have investigated the fundamental inflammation
response of ferrets, in which neutrophils play an important
role.
Polymorphonuclear cells (PMNs) adhere to endothelial
cells in the blood vessels at sites of infection and inflamma-
tion, then, the PMNs infiltrate into tissues showing active
chemotaxis.
...
Moreover,
PMNs are also activated with chemotactic factors, immuno-
complexes, and cytokines and have strong relevance to the
first line of defense against infections
END QUOTED SEGMENTS
BEGIN QUOTE
Thalamus Relat Syst. 2005 Jun;3(2):133-139.
Temporal properties of feedforward and feedback pathways between the
thalamus and visual cortex in the ferret.
Briggs F, Usrey WM.
Center for Neuroscience, University of California, Davis, CA 95618, USA.
This study examines the temporal properties of geniculocortical and
corticogeniculate (CG) pathways that link the lateral geniculate
nucleus (LGN) and primary visual cortex in the ferret. Using
electrical stimulation in the LGN to evoke action potentials in
geniculocortical and CG axons, results show that conduction latencies
are significantly faster in geniculocortical neurons than in CG
neurons. Within each pathway, axonal latency and visual physiology
support the view of sub-classes of neurons. By examining the timing of
visual responses and the latency of CG feedback, estimates indicate
that visual information can reach the cortex and return to the LGN as
early as 60 msec following the onset of a visual stimulus. These
findings place constraints on the functional role of corticogeniculate
feedback for visual processing.
PMID: 18176624 [PubMed - author manuscript in PMC]
END QUOTE
Full article: http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18176624
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