From:
Sukie Crandall
Date: 2008-01-22 20:10:36 UTC
Subject: [ferrethealth] Abstract: a croton extract, Zangrado, studied for itching, nausea, irritated bowel
To: ferrethealth@yahoogroups.com
>
Abstract: a croton extract, Zangrado, studied for itching, nausea, irritated bowel:
The full article for the abstract below can be read for free from link
here:
http://www.translational-medicine.com/content/6/1/3
or go directly to
http://www.translational-medicine.com/content/pdf/1479-5876-6-3.pdf
> J Transl Med. 2008 Jan 18;6(1):3 [Epub ahead of print]
> Miller MJ, Reuter BK, Wallace JL, Sharkey KA.
> ABSTRACT: BACKGROUND: We examined the therapeutic potential of a
> proprietary Croton palanostigma extract (Zangrado) in the management
> of emesis and itch. Methods: Emesis was induced in ferrets with
> morphine-6-glucuronide (0.05 mg/kg sc) in the presence of Zangrado
> (3 mg/kg, ip) and the cannabinoid receptor 1 antagonist, AM 251 (5
> mg/kg, ip). Topical Zangrado (1%) was assessed for anti-pruretic
> actions in the 5-HT-induced scratching model in rats and evaluated
> in capsaicin-induced gastric hyperemia as measured by laser doppler
> flow. In the ApcMin mouse model of precancerous adenomatosis
> polyposis, mice received Zangrado (100 ug/ml in drinking water) from
> the age of 6 -16 weeks for effects on polyp number. In RAW 264.7
> cells Zangrado was examined for effects on lipopolysaccharide-
> induced nitrite production. Results: Zangrado was a highly effective
> anti-emetic, reducing morphine-induced vomiting and retching by 77%.
> These benefits were not associated with sedation or hypothermia and
> were not reversed by cannabinoid receptor antagonism. Itch responses
> were blocked in both the morphine and 5-HT models. Zangrado did not
> exacerbate the ApcMin condition rather health was improved.
> Capsaicin-induced hyperemia was blocked by Zangrado, which also
> attenuated the production of nitric oxide by activated macrophages.
> Conclusion: Zangrado is an effective anti-emetic and anti-itch
> therapy that is devoid of common side-effects, cannabinoid-
> independent and broadly suppresses sensory afferent nerve
> activation. This complementary medicine represents a promising new
> approach to the management of nausea, itch and irritable bowel
> syndrome.
> PMID: 18205911 [PubMed - as supplied by publisher]
>
>
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
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