From:
"Jeff"
Date: 2008-01-30 12:39:53 UTC
Subject: [ferrethealth] Re: older ferret with insulinoma, one previous surgery, on pediapred but....
To: <ferrethealth@yahoogroups.com>
When we used Diazoxide I can't say that we saw any kind of noticeable difference, but then again, we may have been dealing with something more severe than just 'normal' insulinoma.
If you aren't doing so already, try dividing the total daily dosage of Prednisolone into three equal doses, given 8 hours apart. We did notice a difference doing this as compared to 2 doses, 12 hours apart.
Here is a past post from Dr. Bruce Williams, with his opinion on Diazoxide:
BEGIN QUOTE:
----- Original Message -----
From: Bruce Williams, DVM
To: ferrethealth@yahoogroups.com
Sent: Tuesday, September 18, 2007 7:32 AM
Dear Meryl:
I can address it right now. Diazoxide is an expensive drug which
rarely if ever works. It is a holdover from the old days when we had
less surgeons doing insulinoma removal, and if your ferret is otherwise
healthy, surgery is always the better option. It should be reserved as
an adjunct to oral prednisone in non-surgical candidates.
Is there an upper limit to prednisone? Technically no, although high
doses for a lng time are often associated with muscle wasting and
excessive deposition of fat (known as pred belly). I have used up to
5mg/lb in cases of lymphoma without horrible side effects, but that is
always a short-term issue, and would not want to try it for a year or
more. If someone is hitting 2 mg/lb/day, I generally strongly suggest
that they look at a surgical option, either nodulectomy, or partial
pancreatectomy.
With kindest regards,
Bruce Williams, DVM
END QUOTE
Jeff
In Memory of Neo
Caring for Trinny, Morphy, Baby Girl, and Luna
[Non-text portions of this message have been removed]
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