From:
Sukie Crandall
Date: 2008-02-05 20:21:28 UTC
Subject: [ferrethealth] abstracts
To: ferrethealth@yahoogroups.com
J Virol Methods. 2008 Feb 1 [Epub ahead of print]
Assessment of bovine herpesvirus 4 based vector in chicken.
Donofrio G, Manarolla G, Ravanetti L, Sironi G, Cavirani S, Cabassi=20
CS, Flammini CF,Rampin T.
Dipartimento di Salute Animale, Sezione di Malattie Infettive degli=20
Animali, Facolt=E0 di Medicina Veterinaria, 43100 Parma, Italy.
The biological characteristics of BoHV-4 make it a good candidate as a=20
gene delivery vector for vaccination purposes. These characteristics=20
include little or no pathogenicity, unlikely oncogenicity, the ability=20
to accommodate large amounts of foreign genetic material, the ability=20
to infect several cell types from different animal species, such as=20
sheep, goats, swine, cats, dogs, rabbits, mink, horses, turkeys,=20
ferrets, monkeys, hamsters, rats, mice, and chickens. In this report,=20
the feasibility to use BoHV-4 based vector in chicken was=20
investigated. Although BoHV-4 was able to replicate, leading to a=20
cytopathic effect in a chicken cell line and infect the chorion=20
allantoic membrane of embryonated eggs, however it was not pathogenic=20
even when a large dose of virus was injected into the chicken. An=20
immune response could be produced against heterologous antigen=20
delivered by a recombinant BoHV-4. These data suggest the feasibility=20
of using BoHV-4 based vector for vaccination purposes in chickens.
PMID: 18243344 [PubMed - as supplied by publisher]
Re: sleep, REM cycles, and kit development:
> Behav Brain Res. 2008 Jan 4 [Epub ahead of print]
> A preliminary study of sleep ontogenesis in the ferret (Mustela=20
> putorius furo).
>
> Thurber A, Jha SK, Coleman T, Frank MG.
> Department of Neuroscience, University of Pennsylvania School of=20
> Medicine, Philadelphia, PA 19104, USA.
> We investigated sleep ontogenesis in the ferret-a placental mammal=20
> that is highly altricial compared to other mammalian species.=20
> Because altriciality is linked with elevated rapid-eye-movement=20
> (REM) sleep amounts during infancy, it was expected that ferret kits=20
> would display very high levels of this state. Longitudinal=20
> polysomnographic measurements were made from 8 ferret kits from=20
> approximately eye-opening (postnatal day [P]30)-P50 using an=20
> experimental routine that minimized the effects of maternal=20
> separation. These data were compared to values from 8 adult ferrets=20
> (>3 months of age) and 6 neonatal cats (mean age: P31.7). We find=20
> that the polygraphic features of REM and non-REM (NREM) sleep are=20
> present by at least P30. Over the next 2 weeks, REM sleep amounts=20
> slightly declined while wakefulness and NREM sleep amounts=20
> increased. However, a comparison to published values from developing=20
> cats and rats showed that the ferret did not exhibit a=20
> disproportionate amount of REM sleep at similar postnatal ages or=20
> relative to a common developmental milestone (eye-opening).
> PMID: 18243360 [PubMed - as supplied by publisher]
>
>
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
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