From:
"Sukie Crandall"
Date: 2008-02-29 17:13:04 UTC
Subject: [ferrethealth] Re: Propecia
To: ferrethealth@yahoogroups.com
Don't forget that Dr. Catherine Delaney does not consider her study of the topic complete
and is currently broadening it, which is exactly the right thing to do.
Be sure to remember, in addition to sections of her post that you quoted in your post,
that Dr. Delaney herself has pointed out that the actual study itself was relatively short (if
memory serves 2 or 3 years) and did not involve a large number of animals.
Her observations of the clinic animals are additional observations which support the
conclusions for the animals she has treated in that location.
Also, remember that she is very careful to point out that she does NOT know if the result
will be the same at different latitudes or among those who use different surgical
approaches.
She lives in the extreme NW of the nation, and light exposure might change things.
Remember that increased light exposure decreases the body's production of melatonin
and as a result increases the body's production of LH and FSH. The ambient amounts of
light in WA or OR will be quite different from TX or FL, and even quite different from NJ or
OH. The problem is that melatonin has its limitations.
Surgeons vary, too. Years ago we had the best surgeon we've ever had. He had teeny tiny
hands and they were extremely sensitive. Even minor injuries to his hand may have hurt
like heck because his nerves worked so well that he could feel sizes of insulinoma tumors
that no one else could. Not only have we never known a veterinary surgeon that good in
our entire lives but only one human surgeon we have known has been of that caliber. So,
a person has to also find out what works best for the treating vet because they don't all
come from one mold, and different approaches work better for different people.
Currently, Dr. Delaney is doing the next, completely logical step. She is broadening the
study to involve a different location and different vets.
There is also a long study directed by Dr. Nico Shoemaker happening in Europe using
deslorelin depot, a related drug which lasts longer and costs less. The manufacturer
applied for permission to sell that specific depot in the U.S. so hopefully it will eventually
be approved.
In addition, a study (hinted about earlier and announced in the latest issue of Ferrets
magazine) by Doctors Bob Wagner and Mark Finkler will be working on what hopefully will
lead to an adrenal disease vaccine which would reduce GnRH levels, in turn preventing
increases in LH and FSH levels in the first place.
Notice that that Dr. Delaney might well be right (or not) on further study because only the
study will tell that so none of us knows yet. What I am saying is just that the further
study hasn't been done yet so all that people have to go on now are impressions of what
works best for their own vets, their area, and their own ferret families. Can't put the cart
before the horse.
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
--- In ferrethealth@yahoogroups.com, "Karen McCabe" <yahoo@...> wrote:
>
> According to Dr. Delaney's studies....
>
> "lupron plus adrenalectomy led to slightly longer lives in the males;
> females receiving lupron alone lived longer than females having
> surgery. All ferrets who receive adrenalectomy need to concurrently
> have hormonal suppression to live the longest, the difference in
> surgical outcome was in the males since the prostate enlargement
> frequently is the life-limiting factor in males, not the size of the
> adrenal tumor itself."
>
> "As 3 month lupron is exorbitantly expensive, and if the 30 day lupron
> is fresh, frozen for no more than 1-3 months, and dosages are not
> missed, there has been no "refractoriness" to it in the 10 years I
> have been using this drug in ferrets on a monthly basis. Some ferrets
> on the study received monthly lupron for nearly 4 years with
> effectiveness until the tumor was beyond pituitary control."
>
> "Note: at my clinic and the Washington Ferret Rescue none of our
> lupron used is over 30 days from mixing and freezing - usually
> considerably less time. We go through over 150 100 mcg doses a month.
> We have not seen refractoriness or lack of effectiveness with this
> drug even used for more than 3 years monthly."
>
> Karen McCabe
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