From:
Sukie Crandall
Date: 2008-04-20 21:12:39 UTC
Subject: [ferrethealth] Abstract: new FIP-like illness in ferrets
To: ferret-l@LISTSERV.FERRETMAILINGLIST.ORG, fhl <ferrethealth@yahoogroups.com>
Wildlife, Marine, and Zoo Animals
Vet Pathol 45:236=96246 (2008)
Clinicopathologic Features of a Systemic Coronavirus-Associated
Disease Resembling Feline Infectious Peritonitis in the Domestic
Ferret (Mustela putorius)
M. M. GARNER, K. RAMSELL, N. MORERA, C. JUAN-SALLE=B4 S, J. JIME=B4 NEZ, =
M. ARDIACA, A. MONTESINOS,
J. P. TEIFKE, C. V. LO=A8 HR, J. F. EVERMANN, T. V. BASZLER, R. W.=20
NORDHAUSEN, A. G. WISE, R. K. MAES,
AND M. KIUPEL
Northwest ZooPath, Monroe, WA (MMG); Southwest Animal Hospital,=20
Beaverton, OR (KR);
ConZOOlting Wildlife Management, Samalu=A8 s, Spain (CJS); Washington=20
Animal Disease Diagnostic
Laboratory, Pullman, WA (JFE, TVB); Friedrich-Loeffler-Institut,=20
Federal Research Institute for
Animal Health, Isle of Riems, Germany (JPT); Department of Biomedical=20
Sciences, College of
Veterinary Medicine, Oregon State University, Corvallis, OR (CVL);=20
California Animal Heath and
Food Safety Laboratory, Davis, CA (RWN); and Diagnostic Center for=20
Population and Animal Health,
Lansing, MI (AGW, RKM, MK)
Abstract. From 2002 to 2007, 23 ferrets from Europe and the United=20
States were diagnosed with
systemic pyogranulomatous inflammation resembling feline infectious=20
peritonitis (FIP). The average age
at the time of diagnosis was 11 months. The disease was progressive in=20
all cases, and average duration of
clinical illness was 67 days. Common clinical findings were anorexia,=20
weight loss, diarrhea, and large,
palpable intra-abdominal masses; less frequent findings included hind=20
limb paresis, central nervous
system signs, vomiting, and dyspnea. Frequent hematologic findings=20
were mild anemia, thrombocyto-
penia, and hypergammaglobulinemia. Grossly, whitish nodules were found=20
in numerous tissues, most
frequently the mesenteric adipose tissue and lymph nodes, visceral=20
peritoneum, liver, kidneys, spleen,
and lungs. One ferret had a serous abdominal effusion.=20
Microscopically, pyogranulomatous
inflammation involved especially the visceral peritoneum, mesenteric=20
adipose tissue, liver, lungs,
kidneys, lymph nodes, spleen, pancreas, adrenal glands, and/or blood=20
vessels. Immunohistochemically,
all cases were positive for coronavirus antigen using monoclonal=20
antibody FIPV3-70. Electron
microscopic examination of inflammatory lesions identified particles=20
with coronavirus morphology in
the cytoplasm of macrophages. Partial sequencing of the coronavirus=20
spike gene obtained from frozen
tissue indicates that the virus is related to ferret enteric=20
coronavirus.
Key words: Coronavirus; feline infectious peritonitis; ferrets;=20
immunohistochemistry; PCR.
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
[Non-text portions of this message have been removed]
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