From:
Sukie Crandall
Date: 2008-04-28 21:37:25 UTC
Subject: [ferrethealth] abstract
To: fhl <ferrethealth@yahoogroups.com>
from Science Direct
http://www.sciencedirect.com/science
BEGIN QUOTE
Copyright =A9 2008 Elsevier Inc. All rights reserved.
Use of a gonadotropin releasing hormone agonist implant as an=20
alternative for surgical castration in male ferrets (Mustela putorius=20
furo)
N.J. Schoemaker, R. van Deijk, B. Muijlaert, M.J.L. Kik, A.M. Kuijten,=20
F.H. de Jong, T.E. Trigg, C.L.J.J. Kruitwagen and J.A. Mol
Department of Clinical Sciences of Companion Animals, Faculty of=20
Veterinary Medicine, Utrecht University, The Netherlands
Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht=20
University, The Netherlands
Department of Internal Medicine, Erasmus Medical Center, Rotterdam,=20
The Netherlands
Peptech Animal Health, North Ryde, New South Wales 2113, Australia
Center of Biostatistics, Utrecht University, The Netherlands
Received 6 November 2007; revised 5 March 2008; accepted 9 March=20
2008. Available online 25 April 2008.
Abstract
Surgical castration in ferrets has been implicated as an etiological=20
factor in the development of hyperadrenocorticism in this species due=20
to a castration-related increase in plasma gonadotropins. In search=20
for a suitable alternative, the effect of treatment with the depot=20
GnRH-agonist implant, deslorelin, on plasma testosterone=20
concentrations and concurrent testes size, spermatogenesis, and the=20
typical musky odor of intact male ferrets was investigated. Twenty-one=20
male ferrets, equally divided into three groups, were either=20
surgically castrated, received a slow release deslorelin implant or=20
received a placebo implant. Plasma FSH and testosterone=20
concentrations, testis size and spermatogenesis were all suppressed=20
after the use of the deslorelin implant. The musky odor in the ferrets=20
which had received a deslorelin implant was less compared to the=20
ferrets which were either surgically castrated or had received a=20
placebo implant. These results indicate that the deslorelin implant=20
effectively prevents reproduction and the musky odor of intact male=20
ferrets and is therefore considered a suitable alternative for=20
surgical castration in these animals.
Keywords: Deslorelin; Gonadotropin; GnRH; Testosterone; Spermatogenesis
END QUOTE
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
[Non-text portions of this message have been removed]
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