From: Donna Baker
Date: 2008-05-14 18:01:44 UTC
Subject: [ferrethealth] Warwick's necropsy results
I just received the necropsy results back from the vet concerning my ferret Warwick. Warwick had the "fungus" in his nasal cavity. I had to say good-bye to Warwick on April 10. The fungus had invaded his brain and he couldn't walk and was very depressed. Despite our best efforts, I think diagnosis came too late to treat him properly for the fungus. His necropsy was done on April 11, 2008. For those of you who can understand all the language in this, here it is. Thanks, donna.
A 5-year-old, male neutered, ferret was submitted for cosmetic necropsy. Autolysis was minimal. The BCS was 3/5. There was a cutaneous/subcutaneous nodule/abscess measuring - 2cm in diameter in the forehead. A sagital section of the head revealed a - 1.5cm, yellow, mineralized, space occupying, discrete nodule at the caudal nasal cavity. The rostral brain (olfactory bulb) is compressed by the described nodule.
Sections of the skin from the head are characterized by a discrete nodule extending from the superficial to the deep dermis. The nodule is composed of epithelioid macrophages, neutrophils, plasma cells and fewer lymphocytes. Admixed with the inflammatory infiltrate there is moderate proliferation of loose connective tissue and neovascularization (granulation tissue). Tissue fragments were scraped from the nodule at the nasal cavity. These tissues are composed of nasal mucosa and bone along with intraluminal necrotic debris admixed with numerous densely packed hyphae forming radiated structures surrounded by degenerating neutrophils. The mucosa is infiltrated with neutrophils and granulomatous inflammation and there is bone destruction. The fungal hyphae are occasionally septated, with parallel walls, acute angle branching and large round edges (fruiting bodies). There is diffuse and severe pulmonary contestion and edema. There are no significant changes in heart,
adrenal, kidney, spleen, or liver.
1) Focally destructive pyogranulomatous rhinitis with numerous fungal hyphae. 2) Focally extensive pyogranulomatous deep dermatitis, head overlying nasal lesion.
This ferret had a severe pyogranulomatous rhinitis that appears to have eroded bone and extended into the overlying skin. Fungal cultures grow both Aspergillus and Mucor although we fell that the histological characteristics of the hyphae most closely resemble Aspergillus sp. The hemi-head was placed in decalcifying solution and sections pending for better characterization of the lesion at the nasal cavity and brain.
1) Specimen - Nose tissue
Aerobic Culture: Escherichia coli
Comments: Moderate growth.
2) Specimen - Skin
Aerobic Culture: No growth.
1) Specimen - Nose tissue
Fungal Culture: Aspergillus sp.
2) Specimen - Nose tissue
Fungal Culture: Mucor sp.
Comments: No growth of Cryptococcus sp.
3) Specimen - Skin
Fungal Culture: No fungal growth.
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