From:
Sukie Crandall
Date: 2008-06-10 01:51:48 UTC
Subject: [ferrethealth] cystic renal disease in ferrets: new abstract on Pub Med
To: fhl <ferrethealth@yahoogroups.com>
BEGIN QUOTED ABSTRACT
Comp Med. 2008 Apr;58(2):161-7.Links
Cystic renal disease in the domestic ferret.
Jackson CN, Rogers AB, Maurer KJ, Lofgren JL, Fox JG, Marini RP.
Division of Comparative Medicine, Massachusetts Institute of
Technology, Cambridge, MA, USA.
Cystic renal diseases in domestic ferrets are a common anecdotal
finding but have received scant systematic assessment. We performed a
17-y, case-control retrospective analysis of the medical records of 97
ferrets housed at our institution between 1987 and 2004, to determine
the prevalence and morphotypes of cystic renal diseases in this
species. Histologic sections stained with hematoxylin and eosin,
Masson trichrome, or periodic acid-Schiff were evaluated by a
comparative pathologist, and statistical analysis of hematologic and
serum chemistry values was correlated with morphologic diagnosis. Of
the 97 available records, 43 were eliminated due to lack of
accompanying tissues. Of the 54 remaining cases, 37 (69% prevalence)
had documented renal cysts, and 14 of the 54 ferrets (26%) had primary
polycystic disease consisting of either polycystic kidney disease
affecting renal tubules or, more commonly, glomerulocystic kidney
disease. Secondary polycystic lesions were identified in 11 ferrets
(20%), and 12 ferrets (22%) exhibited focal or isolated tubular cysts
only as an incidental necropsy finding. Ferrets with secondary renal
cysts associated with other developmental anomalies, mesangial
glomerulopathy, or end-stage kidney disease had hyperphosphatemia and
elevated BUN in comparison with those with primary cystic disease and
elevated BUN compared with those without renal lesions. Although
reflecting institutional bias, these results implicate primary and
secondary cystic renal diseases as highly prevalent and underreported
in the domestic ferret. In addition to the clinical implications for
ferrets as research subjects and pets, these findings suggest a
potential value for ferrets as a model of human cystic renal diseases.
PMID: 18524174
END QUOTED ABSTRACT
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
[Non-text portions of this message have been removed]
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