From:
Sukie Crandall
Date: 2008-09-04 03:29:55 UTC
Subject: [ferrethealth] abstract: coagulation values for ferrets
To: fhl <ferrethealth@yahoogroups.com>
Vet Clin Pathol. 2008 Sep;37(3):286-8.
Coagulation values in normal ferrets (Mustela putorius furo) using
selected methods and reagents.
Benson KG, Paul-Murphy J, Hart AP, Keuler NS, Darien BJ.
Department of Medical Sciences, School of Veterinary Medicine,
University of Wisconsin, Madison, WI.
Background: Accurate determination of commonly measured coagulation
values would be useful in the diagnosis and management of
coagulopathies in domestic ferrets (Mustela putorius furo). We are
unaware of reports of coagulation times in this species. Objectives:
The purpose of this study was to determine reference values for
prothrombin time (PT), activated partial thromboplastin time (PTT),
fibrinogen concentration, and antithrombin (AT) activity in ferrets
using selected methods and reagents. Methods: Blood samples obtained
from 18 clinically healthy ferrets were anticoagulated with 0.129 M
sodium citrate in a ratio of 9 parts blood to 1 part anticoagulant.
Plasma was collected and stored at -70 degrees C until analysis. PT
and PTT were measured with a fibrometer and with an ACL 3000 automated
system. PTT was measured with and without the addition of ellagic
acid. Fibrinogen was assayed by a turbidimetric method. AT activity
was determined using a chromogenic assay and pooled ferret plasma
(100% activity). Differences in methods and reagents were evaluated
using paired t tests. Results: PT was significantly longer using the
fibrometer (12.3+/-0.3, 11.6-12.7 seconds) compared with the ACL
(10.9+/-0.3, 10.6-11.6 seconds) (P<.01). PTT was not significantly
different with the fibrometer (18.7+/-0.9, 17.5-21.1 seconds) vs the
ACL (18.1+/-1.1, 16.5-20.5 seconds), but was significantly longer on
both analyzers when ellagic acid was added (fibrometer 20.4+/-0.8,
18.9-22.3 seconds; ACL 20.0+/-1.0, 18.6-22.1 seconds) (P<.01).
Fibrinogen concentration was 107.4+/-19.8 mg/dL (90.0-163.5 mg/dL),
and AT activity was 96%+/-12.7% (69.3-115.3%). Conclusion: These
coagulation results for healthy ferrets will be useful in the
evaluation of ferrets with coagulopathies, provided similar reagents
and methods are used.
PMID: 18761520
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
[Non-text portions of this message have been removed]
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