From:
Sukie Crandall
Date: 2008-09-05 18:51:45 UTC
Subject: [ferrethealth] Re: Hind leg weakness
To: fhl <ferrethealth@yahoogroups.com>
Perhaps the vet had a different lab measure at least some of the same
things as the TN Panel.
Not really finding anything which answers why that med was given, but=20
maybe some hints of why the vet wanted to try it...
http://www.ncbi.nlm.nih.gov/pubmed/11492956
http://www.ncbi.nlm.nih.gov/pubmed/11098835
BEGIN QUOTES
Z Naturforsch [C]. 2000 Sep-Oct;55(9-10):806-13.Links
Exogenous melatonin elevates the plasma leptin and thyroxine=20
concentrations of the mink (Mustela vison).
Mustonen AM, Nieminen P, Hyv=E4rinen H, Asikainen J.
Department of Biology, University of Joensuu, Finland. ammusto@cc.joensuu.f=
i
Eight male and eight female minks were given exogenous melatonin as=20
subcutaneous implants. The plasma leptin and thyroxine concentrations=20
were measured. The leptin concentrations showed clear seasonal=20
variations and differences between the experimental groups. In=20
September most of the control females had undetectable plasma leptin=20
concentrations, but the melatonin-treated females had detectable=20
concentrations significantly higher than the leptin levels of the=20
controls. Most of the males had undetectable leptin concentrations,=20
too. In October the plasma leptin levels had increased significantly=20
in all the groups except the control males. The melatonin-treated=20
minks had significantly higher leptin levels than the controls. There=20
was a significant rise in the thyroxine levels from September to=20
October and the melatonin-treated groups had significantly higher=20
thyroxine levels than the controls. The effects of exogenous melatonin=20
are very pronounced in the mink. Melatonin elevates the plasma leptin=20
and thyroxine levels possibly by direct and indirect mechanisms.
PMID: 11098835
Jpn J Physiol. 2001 Jun;51(3):319-26.
Cross-bridge and calcium behavior in ferret papillary muscle in=20
different thyroid states.
Yagi N, Saeki Y, Ishikawa T, Kurihara S.
Department of Pharmacology, Tohoku University School of Medicine,=20
Sendai, 980-8575 Japan. yagi@spring8.or.jp
X-ray diffraction studies were made using synchrotron radiation on=20
ferret right ventricular papillary muscle under three different=20
thyroid states: euthyroidism, hyperthyroidism, and hypothyroidism. The=20
latter two states were induced by treatment with L-thyroxine and=20
methimazole, respectively. The X-ray equatorial reflections were=20
recorded at a time resolution of 10 ms to study the mass movement of=20
myosin cross-bridges from thick to thin filaments. The myosin isomer=20
content was measured by gel electrophoresis which showed that V3=20
isomer was predominant in euthyroid muscle and 27% of myosin was V1=20
isomer in hyperthyroid muscle. The intracellular free Ca concentration=20
was measured by using the aequorin method. The peak Ca concentration=20
was similar in all three states, but in the hypothyroid state the time-
to-peak was longer and the decay was slower. The time-to-peak of=20
twitch tension was shorter in hyperthyroidism and longer in=20
hypothyroidism than in euthyroidism. The different time courses of=20
twitch tension in different thyroid states accompanied a cross-bridge=20
movement which closely followed the tension development. In=20
hyperthyroidism, the cross-bridge movement significantly preceded=20
tension development, suggesting that hyperthyroid myosin (V1) has a=20
longer latency period between the shift to the vicinity of the thin=20
filament and force development.
END QUOTES
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
[Non-text portions of this message have been removed]
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