From:
"Jeff"
Date: 2008-09-24 06:45:15 UTC
Subject: [ferrethealth] Re: older ferret with insulinoma, one previous surgery, on pediapred but....
To: <ferrethealth@yahoogroups.com>
Here is a past post (below) from Dr. Williams that you might be interested in, as he's not a fan of Diazoxide. From my own experience, I can tell you that we had no real positive reaction when using it with Neo, but there is a possibility that he had carcinoma of the pancreas, not 'just' insulinoma, as it progressed extremely fast. Also, Neo was already on high doses of Prednisolone when the Diazoxide was added. My over all understanding is that some ferrets can benefit from it, but results can vary widely.
Jeff
In Memory of Neo
Caring for Trinny, Morphy, Baby Girl, Luna, and Dozer
http://ferrethealth.org/archive/FHL2551
----- Original Message -----
From: Bruce Williams, DVM
To: ferrethealth@yahoogroups.com
Sent: Tuesday, September 18, 2007 7:32 AM
Dear Meryl:
I can address it right now. Diazoxide is an expensive drug which
rarely if ever works. It is a holdover from the old days when we had
less surgeons doing insulinoma removal, and if your ferret is otherwise
healthy, surgery is always the better option. It should be reserved as
an adjunct to oral prednisone in non-surgical candidates.
Is there an upper limit to prednisone? Technically no, although high
doses for a lng time are often associated with muscle wasting and
excessive deposition of fat (known as pred belly). I have used up to
5mg/lb in cases of lymphoma without horrible side effects, but that is
always a short-term issue, and would not want to try it for a year or
more. If someone is hitting 2 mg/lb/day, I generally strongly suggest
that they look at a surgical option, either nodulectomy, or partial
pancreatectomy.
With kindest regards,
Bruce Williams, DVM
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