From:
Sukie Crandall
Date: 2008-10-20 18:12:29 UTC
Subject: [ferrethealth] Re: Lymphnode Question...
To: fhl <ferrethealth@yahoogroups.com>
Tressie, I suspect that you are barking up the wrong tree with this.
Dr. Williams has often warned that people not generalize what is=20
carcinogenic for one species to another. The first time I read him=20
saying that he was talking about one or more food preservatives that=20
were problems in rodents. The TYPES OF MALIGNANCIES (always important=20
to notice) that increased in the rodents with huge levels of=20
preservatives were ones that ferrets almost never get. On the other=20
hand, there was a type of malignancy that ferrets do get which was in=20
LOWER levels in those rodents who had the preservative.
Makes a person realize who misleading a generalization can become at=20
times...
Literally, food for thought!
One of the problems with rodent and primate studies is that they are=20
somewhat closely related to each other, but NOT to members of=20
Carnivora, so a consideration in those Orders is not necessarily going=20
to apply to ferrets or other members of Carnivora.
In
http://www.ncbi.nlm.nih.gov/pubmed/3773544
which is about dogs (since I could find no ferrets in such work and=20
ferrets -- though they differ a good bit from dogs are descended from=20
the canid branch of Carnivora) it looks like they introduced OTHER=20
things which can cause malignancy and the role the Imuran played in=20
the development of malignancy was that works as an immunosuppressant=20
so the body could not fight off the early malignant cells.
The immunosuppressant aspect could be a consideration now, certainly.
In
http://www.ncbi.nlm.nih.gov/pubmed/15086092
the med was part of the treatment after removal of a malignancy.
This might or might not indicate that something in the future might be=20
found to support Tressie's premise. The chain is way too unclear to=20
know causality for sure:
http://www.ncbi.nlm.nih.gov/pubmed/14756205
So, it looks like the question becomes whether the immunosuppression=20
might be useful with this specific form of malignancy or not.=20=20
REMEMBER THAT PRED IS ALSO AN IMMUNOSUPPRESSANT AND OFTEN USED FOR=20
THOSE WITH MALIGNANCIES WITH GOOD RESULTS, AND THE IMURAN IS A FORM OF=20
CHEMOTHERAPY USED IN ONCOLOGY.
Tressie wrote:
> Rhenne,
>
> There are a number of animal studies that show Azathioprine is
> carcinogenic.
>
> Here are some references:
>
> FDA's official position: "Azathioprine is mutagenic in animals and
> humans, carcinogenic in animals=85"
> (http://www.drugs.com/pro/azathioprine.html
> <http://www.drugs.com/pro/azathioprine.html> )
>
>
>
> " Other potential side effects of azathioprine include severe anemia
> or or leukopenia (shortage of white blood cells), liver damage, and a
> long-term increased risk of developing cancers such as leukemia or
> lymphoma."
> (http://www.msviewsandrelatednews.com/blog5/index.php?itemid=3D121
>
>
>
> http://cancerres.aacrjournals.org/cgi/reprint/43/6/2768.pdf
> <http://cancerres.aacrjournals.org/cgi/reprint/43/6/2768.pdf>
>
>
>
> http://www.inchem.org/documents/iarc/suppl7/azathioprine.html
> <http://www.inchem.org/documents/iarc/suppl7/azathioprine.html>
>
>
>
> http://www.springerlink.com/content/h1720701x76225lq/
> <http://www.springerlink.com/content/h1720701x76225lq/>
>
>
>
> http://books.google.ca/books?id=3DdYlkcnj6QpQC&pg=3DPA152&lpg=3DPA152&dq=
=3Dazath
> \
> ioprine+and+lymphoma+in
> +animals&source=3Dweb&ots=3DfR6CwUy1Av&sig=3DXOMCLAOWq1\
> 9Hv6qayj7GZ-CfxeU&hl=3Den&sa=3DX&oi=3Dbook_result&resnum=3D10&ct=3Dresult
> <http://books.google.ca/books?id=3DdYlkcnj6QpQC&pg=3DPA152&lpg=3DPA152&dq=
=3Dazat
> \
> hioprine+and+lymphoma+in
> +animals&source=3Dweb&ots=3DfR6CwUy1Av&sig=3DXOMCLAOWq\
> 19Hv6qayj7GZ-CfxeU&hl=3Den&sa=3DX&oi=3Dbook_result&resnum=3D10&ct=3Dresul=
t>
>
>
>
> Unfortunately it may be that Azathioprine may have exacerbated=20
> possible
> lymphoma and not masked it, although the studies cited were not=20
> specific
> to ferrets. Since it is commonly prescribed for ferrets with IBD and=20
> EGE
> I would think clinical trials have established its safety for use in
> ferrets and it may be that it is not carcinogenic in ferrets.=20=20
> However,
> I was not able to find any such studies. This does not mean that they
> do not exist, only that I was unable to locate them.
>
>
>
> This information will need to be discussed with your veterinarian.
>
>
>
> Good luck!
>
>
>
> Tressie
>
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
[Non-text portions of this message have been removed]
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