From:
"Tressie"
Date: 2008-10-20 15:29:30 UTC
Subject: [ferrethealth] Re: Lymphnode Question...
To: ferrethealth@yahoogroups.com
Rhenne,
There are a number of animal studies that show Azathioprine is
carcinogenic.
Here are some references:
FDA's official position: "Azathioprine is mutagenic in animals and
humans, carcinogenic in animals=85"
(http://www.drugs.com/pro/azathioprine.html
<http://www.drugs.com/pro/azathioprine.html> )
" Other potential side effects of azathioprine include severe anemia
or or leukopenia (shortage of white blood cells), liver damage, and a
long-term increased risk of developing cancers such as leukemia or
lymphoma."
(http://www.msviewsandrelatednews.com/blog5/index.php?itemid=3D121
http://cancerres.aacrjournals.org/cgi/reprint/43/6/2768.pdf
<http://cancerres.aacrjournals.org/cgi/reprint/43/6/2768.pdf>
http://www.inchem.org/documents/iarc/suppl7/azathioprine.html
<http://www.inchem.org/documents/iarc/suppl7/azathioprine.html>
http://www.springerlink.com/content/h1720701x76225lq/
<http://www.springerlink.com/content/h1720701x76225lq/>
http://books.google.ca/books?id=3DdYlkcnj6QpQC&pg=3DPA152&lpg=3DPA152&dq=3D=
azath\
ioprine+and+lymphoma+in+animals&source=3Dweb&ots=3DfR6CwUy1Av&sig=3DXOMCLAO=
Wq1\
9Hv6qayj7GZ-CfxeU&hl=3Den&sa=3DX&oi=3Dbook_result&resnum=3D10&ct=3Dresult
<http://books.google.ca/books?id=3DdYlkcnj6QpQC&pg=3DPA152&lpg=3DPA152&dq=
=3Dazat\
hioprine+and+lymphoma+in+animals&source=3Dweb&ots=3DfR6CwUy1Av&sig=3DXOMCLA=
OWq\
19Hv6qayj7GZ-CfxeU&hl=3Den&sa=3DX&oi=3Dbook_result&resnum=3D10&ct=3Dresult>
Unfortunately it may be that Azathioprine may have exacerbated possible
lymphoma and not masked it, although the studies cited were not specific
to ferrets. Since it is commonly prescribed for ferrets with IBD and EGE
I would think clinical trials have established its safety for use in
ferrets and it may be that it is not carcinogenic in ferrets. However,
I was not able to find any such studies. This does not mean that they
do not exist, only that I was unable to locate them.
This information will need to be discussed with your veterinarian.
Good luck!
Tressie
--- In ferrethealth@yahoogroups.com, "rhenne79" <berkana_@...> wrote:
...> Could the medicine for IBD be helping to suppress the progression
of
> the lymphoma? or perhaps this is just a coincidence.
>
[Non-text portions of this message have been removed]
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