Message Number: FHL6533 | New FHL Archives Search
From: ferretgm
Date: 2008-10-28 14:48:55 UTC
Subject: [ferrethealth] Interpretation of hepatic swelling passage in Williams article

Can someone tell me whether the "hepatocellular swelling which may be marke=
d" in the below passage (from
ets/Clin_Path/ClinPath.html) refers to a change that would only be noticeab=
le at the cellular level, or whether it refers to an enlargement of the ent=
ire liver?=A0
start quote:
Probably the most common misinterpretation that I see on a routine basis is=
in the area of hepatic enzymes. Remember, that the ferret, being by nature=
an obligate carnivore, has an extremely short digestive tract, and require=
s meals as often as every four to six hours. Should food not be available, =
it possesses the ability to quickly mobilize peripheral fat stores in order=
to meet energy requirements. When this physiologic mechanism is activated,=
the liver is literally flooded with fat, which results in hepatocellular s=
welling which may be marked. The result of this swelling is the leakage of =
membrane enzymes such as alanine aminotransferase, and as the hepatocellula=
r swelling increases, occlusion of bile canaliculi occurs, resulting, over =
time, in elevation of alkaline phosphatase.
end quote.
Does anyone know of (other) reasons that the entire liver would enlarge in =
the absence of signs of infection (the various types of white blood cells a=
re normal to only very, very slightly elevated)?=A0
Thanks in advance.


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