From:
"Tony Clarke"
Date: 2008-11-15 00:18:05 UTC
Subject: [ferrethealth] Re: Nic Nac's blood panel
To: ferrethealth@yahoogroups.com
> On Tue, Nov 11, 2008 at 10:47 AM, Cindy Scheidt <ScheidtC@...
> wrote:
> A new CBC with manual differential was done, and anemia comes up
> again (hct 39%). There are unfamiliar (to me) items in the
> differential.
> It would be great if someone in the know could tell us if they are
> significant in this overall picture. For instance, I can do a
> search a learn the definition of polychromasia, but I don't know how
> significant +3 is. The original sheet of results is scanned and
> available at the above URL, but for convenience:
>
> WBC 5.28
> RBC 8.100
> HGB 13.3
> HCT 39.1
> MCV 48.3
> MCH 16.4
> MCHC 34.0
> Platelet estimate adequate.
>
> Manual Differential
> SEGS 64
> BANDS 0
> LYMPHS 23
> MONOS 10
> EOS 3
> POLYCHROMASIA +3
> HYPOCHROMASIA +1
> POIKILOCYTOSIS +1
> ANISOCYTOSIS +2
> OVALOCYTES OCC
> STOMATOCYTES OCC
> HOWELL JOLLY BODIES +1
Some caution maybe needed here...
If this blood sample was taken under anesthesia (isoflurane) then
HCT and HGB will have a lower than the true value.
See..
Distribution of technetium 99m-labeled red blood cells during
isoflurane anesthesia in ferrets ( PMID: 9215458).
and...
and an extract from US vet school (University of Georgia)
http://www.vet.uga.edu/VPP/clerk/kim/index.htm
START QUOTE
Problem 2 - Moderate anemia
The complete blood count (CBC), taken at the time of peripheral
lymphadenopathy, revealed a moderate anemia with a decreased red
blood cell (RBC) count and hemoglobin (Hb) concentration. The
reticulocyte count and plasma protein concentration were not
assessed. Anemia may reflect red blood cell loss, destruction,
decreased or ineffective erythropoiesis, or hemodilution from
intravenous fluid administration. The blood sample was collected
under isoflurane anesthesia. In ferrets, isoflurane anesthesia has
been associated with a transient but marked decrease in hematocrit
(Hct), RBC and Hb concentration values. Greater than 30% difference
was noted in these indices when comparing pre-anesthetic and
anesthetic blood samples from individual healthy ferrets. The
mechanism of this phenomenon is unknown.
When the CBC was repeated 22 days later (on the conscious patient),
the Hct and Hb values were just slightly below reference intervals.
Given the variations in the published reference ranges for ferrets,
these values could fall within the low end of the reference range.
Without evidence of hemorrhage, hemolysis, or regeneration, the
initial change in Hct was attributed to the effects of isoflurane.
END QUOTE
Tony (not a vet), Sugar and Suki.
In memory of Sally and Sue
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