From:
"Sukie Crandall"
Date: 2008-11-22 17:05:49 UTC
Subject: [ferrethealth] Re: Posting Nic Nac's info for Cindy and Vickie
To: ferrethealth@yahoogroups.com
Sorry about trying to work when I was WAY too
sleepy last night. I badly wanted to make sure
that Nic Nac's vet would have references in case
people who knkow way more than I do decide
that zinc poisoning might fit.
Just to be thorough about heavy metal poisoning
for the archives references in general include:
BEGIN QUOTE OF ABSTRACTS
J Am Vet Med Assoc. 1994 Oct 15;205(8):1154-6.Links
Copper toxicosis in sibling ferrets.
Fox JG, Zeman DH, Mortimer JD.
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge
02139.
Two sexually intact female silver-shaded domestic ferret siblings from different litters
were examined because of CNS depression and lethargy. Ferret 1 was dehydrated and
hypothermic, whereas ferret 2 was icteric and febrile and had serum bilirubin
concentration > 12.0 mg/dl and BUN of 59 mg/dl. Despite supportive treatment, the
ferrets died within days of evaluation. On necropsy, ferret 1 had chronic hepatopathy, with
diffuse vacuolation of hepatocytes. In ferret 2, the liver had centrilobular degeneration and
necrosis, and hemoglobinuric nephrosis was evident, with hemoglobin in the renal
tubules. In both ferrets, Kupffer's cells and macrophages contained eosinophilic material
in the cytoplasm. Special staining revealed copper pigment in hepatocytes and phagocytic
cells in both livers. Analysis of liver specimens revealed 850 and 700 ppm of copper in
ferrets 1 and 2, respectively. Copper values > 200 ppm in liver are considered evidence of
toxicosis in most animal species. Copper toxicosis was diagnosed on the basis of the
findings from histologic examination of the liver and high hepatic copper values. Lack of
related illness in 11 other ferrets in the same environment and fed the same diet, plus
sibling relationship and same phenotypic coat color in the affected ferrets, suggested that
these ferrets had an inherited defect in their ability to metabolize normal amounts of
ingested copper.
PMID: 7890574
Vet Clin North Am Small Anim Pract. 1990 Mar;20(2):539-44.Links
Toxicology of selected pesticides, drugs, and chemicals. Zinc.
Robinette CL.
Department of Anatomy, North Carolina State University College of Veterinary Medicine,
Raleigh.
Zinc poisoning in small animals has been described in dogs, cats, birds, and ferrets, but
the dog appears to be the species most often affected. Ingestion of zinc-containing
metallic objects, including pennies, and zinc oxide ointments has been associated with the
majority of the toxicoses. Clinical signs include anorexia, vomiting, diarrhea, hemolytic
anemia, kidney dysfunction, and possible liver and pancreatic abnormalities. Treatments
that have proven efficacious include fluid diuresis, blood transfusions as needed, general
supportive care, and removal of the source of zinc. Further evaluation of the benefit of
chelation therapy is urgently needed.
PMID: 2180195
Lab Anim. 1981 Jan;15(1):45-7. Links
Zinc poisoning in ferrets (Mustella putoris furo).
Straube EF, Walden NB.
PMID: 7265896
[I included a direct link to the above article in full in a
post yesterday.]
Acta Vet Scand. 1970;11(2):268-82.Links
Poisoning in ferrets by tissues of alkyl mercury-fed chickens.
Hanko E, Erne K, Wanntorp H, Borg K.
PMID: 5449102
END QUOTES
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