From:
Sukie Crandall
Date: 2008-12-08 00:36:25 UTC
Subject: [ferrethealth] abstracts
To: fhl <ferrethealth@yahoogroups.com>
BEGIN QUOTES
Vet Clin Pathol. 2008 Dec;37(4):443-446.
What is your diagnosis? Preputial mass in a ferret.
Pinches MD, Liebenberg G, Stidworthy MF.
Greendale Veterinary Diagnostics, Woking, Surrey, UK;
: A 7-year-old neutered male polecat-type ferret (Mustela putorius
furo) was presented for evaluation of a cutaneous mass close to the
preputial orifice. Cytologic examination of a fine-needle aspirate
revealed numerous large clumps of amorphous pink mucinous material and
numerous large clumps of slightly pleomorphic epithelial cells. The
cells were arranged in papillary structures, palisades, and loosely
cohesive sheets with a vaguely honeycomb appearance. Occasional acinar
formations were also seen. The cells had moderate to large amounts of
finely granular gray to gray-blue cytoplasm. The cells were round to
wispy and elongated, with indistinct borders. Often, anuclear
cytoplasmic clumps were seen free in the background or adjacent to
intact cells. Nuclei were round to oval and usually off-center.
Chromatin was finely stippled and contained 1-3 indistinct nucleoli.
Anisokaryosis and anisocytosis were moderate. Binucleated cells were
noted occasionally. The cytologic features were consistent with a
carcinoma of probable apocrine origin. Histopathologic examination
supported a diagnosis of secretory apocrine adenocarcinoma of the
preputial skin. Secretory apocrine adenocarcinomas of the prepuce are
seen relatively frequently in ferrets, although their cytologic
appearance has not been described widely. These neoplasms carry a poor
prognosis although prompt surgical removal with wide and deep surgical
margins and adjunctive radiotherapy may improve survival.
PMID: 19055582
Vaccine. 2008 Nov 18. [Epub ahead of print]
Influenza-pseudotyped Gag virus-like particle vaccines provide broad
protection against highly pathogenic avian influenza challenge.
Haynes JR, Dokken L, Wiley JA, Cawthon AG, Bigger J, Harmsen AG,
Richardson C.
LigoCyte Pharmaceuticals, Inc. 2155 Analysis Dr., Bozeman, MT 59718,
USA.
Influenza-pseudotyped Gag virus-like particles (VLPs) were produced
via the expression of influenza hemagglutinin (HA), neuraminidase (NA)
and the murine leukemia virus Gag product in the baculovirus-insect
cell expression system. Hemagglutination specific activities of
sucrose gradient-purified VLPs were similar to those of egg-grown
influenza viruses but particle morphologies were gamma retrovirus-like
in the form of consistent 100nm spheres. Immunization of mice and
ferrets demonstrated robust immunogenicity and protection from
challenge with no measurable morbidity. Ferret data were striking in
that immunization with H5N1 VLPs representing either A/Vietnam/1203/04
or A/Indonesia/5/05 resulted in solid protection against highly
pathogenic A/Vietnam/1203/04 challenge with no detectable virus in the
upper respiratory tract post-challenge in either group. H1N1 VLP
immunization of ferrets resulted in partial protection against H5N1
challenge with markedly accelerated virus clearance from the upper
respiratory tract relative to controls. The immunogenicity of
influenza-pseudotyped VLPs was not dependent on the adjuvant
properties of replication competent contaminating baculovirus. These
data demonstrate robust vaccine protection of Gag-based, influenza-
pseudotyped VLPs carrying a variety of influenza antigens and suggest
applicability toward a number of additional respiratory viruses.
PMID: 19026705
END QUOTES
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
[Non-text portions of this message have been removed]
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