From:
Sukie Crandall
Date: 2008-12-27 21:05:17 UTC
Subject: [ferrethealth] Re: Intestinal Lymphoma and yellow mucus diarrhea
To: fhl <ferrethealth@yahoogroups.com>
These abstracts may be useful, but you'll want more info than they
have, such as the info which would tell which chemo protocols were
used for the various types since some may be more successful than
others:
http://www.ncbi.nlm.nih.gov/pubmed/18725471
http://www.ncbi.nlm.nih.gov/pubmed/18840962
BEGIN QUOTES
Vet Pathol. 2008 Sep;45(5):663-73.
Laboratory findings, histopathology, and immunophenotype of lymphoma
in domestic ferrets.
Ammersbach M, Delay J, Caswell JL, Smith DA, Taylor WM, Bienzle D.
Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1
(Canada).
Lymphoma is a common tumor in ferrets, but anatomic distribution,
histomorphology, immunophenotype, laboratory abnormalities, and
response to chemotherapy are incompletely defined. In this study,
lymphoma was diagnosed by histopathology of tumor tissue in 29 ferrets
ranging in age from 0.8 to 8.5 years, including 12 males and 17
females. Tumors involved the viscera of the abdominal cavity (n = 11),
thoracic cavity (n = 1), or abdominal and thoracic cavities (n = 7);
the skin (n = 2); or the viscera of both body cavities plus other
sites (n = 8). Microscopically, all tumors had diffuse architecture.
Assessment by histomorphology and immunophenotype classified tumors as
peripheral T-cell lymphoma (n = 17), anaplastic large T-cell lymphoma
(n = 5), anaplastic large B-cell lymphoma (n = 4), diffuse large B-
cell lymphoma (n = 1), and Hodgkin-like lymphoma (n = 2). Cytologic
evaluation of tumor tissue was diagnostic in 11 of 13 cases. Twenty-
two of 27 ferrets had anemia, 2 had leukemia, and 5 were neutropenic.
Common comorbid disorders were adrenal disease (n = 27) and insulinoma
(n = 6). Tumors most frequently involved mesenteric lymph nodes, while
enlargement of peripheral lymph nodes was uncommon (n = 3). Ferrets
with Hodgkin-like lymphoma had massive enlargement of single lymph
nodes. Mean survival of ferrets not immediately euthanized was 5.0
months (T-cell lymphoma) and 8.4 months (B-cell lymphoma). Ferrets
treated with chemotherapy survived an average of 4.3 months (T-cell
lymphoma, n = 9) or 8.8 months (B-cell lymphoma, n = 4). Results
indicate that lymphomas in ferrets most commonly affect abdominal
viscera, may be amenable to cytologic diagnosis, are frequently
associated with anemia and, in some cases, may be chemosensitive,
resulting in relatively long survival times.
PMID: 18725471
J Vet Med Sci. 2008 Sep;70(9):893-8.
Cytomorphological and immunohistochemical features of lymphoma in
ferrets.
Onuma M, Kondo H, Ono S, Shibuya H, Sato T.
Onuma Animal Hospital, Saitama, Japan. rin@rc4.so-net.ne.jp
Twenty ferrets with histopathologically diagnosed lymphoma were
classified cytomorphologically and immunohistochemically. According to
site of origin, multicentric, gastrointestinal, mediastinal and
cutaneous lymphomas accounted for 8 (40%), 9 (45%), 2 (10%) and 1 case
(5%), respectively. According to the National Cancer Institute Working
Formulation (NCI-WF), low-, high- and intermediate-grade lymphomas
accounted for 4 (20%), 4 (20%) and 12 cases (60%), respectively. The 4
low-grade lymphomas showed no mitotic figures, whereas all 4 high-
grade lymphomas exhibited > or = 3 mitotic figures (median,6). Higher
grade thus appears to be associated with a higher number of mitotic
figures. Immunohistochemical examination of 18 specimens, excluding 2
insufficient specimens, showed that 16 (88.9%) and 2 (11.1%) lymphomas
were of T-cell origin and B-cell origin, respectively. According to
the combination of the NCI-WF and immunophenotypes, all 4 low-grade
lymphomas (2 multicentric, 1 gastrointestinal, and 1 cutaneous
lymphoma) were classified as diffuse small lymphocytic lymphoma of T-
cell origin. Of the 12 intermediate-grade lymphomas (6 multicentric, 4
gastrointestinal, and 2 mediastinal lymphomas), 11 were classified as
diffuse mixed-cell lymphoma, and 1 as diffuse large cell lymphoma. Of
these 11 lymphomas, 2 (both multicentric) were of B-cell origin, 7 (3
multicentric, 3 gastrointestinal, 1 mediastinal) were of T-cell
origin, and 2 (1 multicentric, 1 mediastinal) were of unknown cell
origin. The remaining 1 lymphoma (gastrointestinal) was of T-cell
origin. All 4 high-grade lymphomas (gastrointestinal) were classified
as diffuse immunoblastic lymphoma of T-cell origin.
PMID: 18840962
END QUOTES
The first requires a subscription for the complete article, but the
second can be read in full at
http://www.jstage.jst.go.jp/article/jvms/70/9/893/_pdf
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
[Non-text portions of this message have been removed]
------------------------------------
Yahoo! Groups Links
<*> To visit your group on the web, go to:
http://groups.yahoo.com/group/ferrethealth/
<*> Your email settings:
Individual Email | Traditional
<*> To change settings online go to:
http://groups.yahoo.com/group/ferrethealth/join
(Yahoo! ID required)
<*> To change settings via email:
mailto:ferrethealth-digest@yahoogroups.com
mailto:ferrethealth-fullfeatured@yahoogroups.com
<*> To unsubscribe from this group, send an email to:
ferrethealth-unsubscribe@yahoogroups.com
<*> Your use of Yahoo! Groups is subject to:
http://docs.yahoo.com/info/terms/