Message Number: FHL10076 | New FHL Archives Search
From: "sukiedaviscrandall"
Date: 2009-10-15 03:03:59 UTC
Subject: [ferrethealth] Re: Ferret with flu

Vicks VapoRub has been demonstrated to be able to
induce respiratory complications in ferrets and
should be avoided:

> Chest. 2009 Jan;135(1):143-8
> Vicks VapoRub induces mucin secretion, decreases ciliary beat
> frequency, and increases tracheal mucus transport in the ferret
> trachea.
> Abanses JC, Arima S, Rubin BK.
> Department of Pediatrics, Wake Forest University School of Medicine,
> Winston-Salem, NC 27157-1081, USA.
> BACKGROUND: Vicks VapoRub (VVR) [Proctor and Gamble; Cincinnati, OH]
> is often used to relieve symptoms of chest congestion. We cared for
> a toddler in whom severe respiratory distress developed after VVR
> was applied directly under her nose. We hypothesized that VVR
> induced inflammation and adversely affected mucociliary function,
> and tested this hypothesis in an animal model of airway
> inflammation. METHODS: [1] Trachea specimens excised from 15 healthy
> ferrets were incubated in culture plates lined with 200 mg of VVR,
> and the mucin secretion was compared to those from controls without
> VVR. Tracheal mucociliary transport velocity (MCTV) was measured by
> timing the movement of 4 microL of mucus across the trachea. Ciliary
> beat frequency (CBF) was measured using video microscopy. [2]
> Anesthetized and intubated ferrets inhaled a placebo or VVR that was
> placed at the proximal end of the endotracheal tube. We evaluated
> both healthy ferrets and animals in which we first induced tracheal
> inflammation with bacterial endotoxin (a lipopolysaccharide [LPS]).
> Mucin secretion was measured using an enzyme-linked lectin assay,
> and lung water was measured by wet/dry weight ratios. RESULTS: [1]
> Mucin secretion was increased by 63% over the controls in the VVR in
> vitro group (p < 0.01). CBF was decreased by 35% (p < 0.05) in the
> VVR group. [2] Neither LPS nor VVR increased lung water, but LPS
> decreased MCTV in both normal airways (31%) and VVR-exposed airways
> (30%; p = 0.03), and VVR increased MCTV by 34% in LPS-inflamed
> airways (p = 0.002). CONCLUSIONS: VVR stimulates mucin secretion and
> MCTV in the LPS-inflamed ferret airway. This set of findings is
> similar to the acute inflammatory stimulation observed with exposure
> to irritants, and may lead to mucus obstruction of small airways and
> increased nasal resistance.
> PMID: 19136404


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