Message Number: FHL10524 | New FHL Archives Search
From: Sukie Crandall
Date: 2009-12-18 15:33:06 UTC
Subject: [ferrethealth] quick note on a genetic discovery that should affect ferret breeder note keeping
To: fhl <>, fg <>, Ferret Mailing List <ferret-l@LISTSERV.FERRETMAILINGLIST.ORG>

There has now been human genetic health research indicating that the=20
same allele can behave differently depending on which parent=20
contributes it.
(Might not be available yet for non-subscribers.)

>> researchers at deCODE genetics in Iceland and colleagues report in=20
>> the Dec. 17 Nature. The team uncovered common single-letter genetic=20
>> changes =97 called SNPs, short for single nucleotide polymorphisms =97 =

>> that were associated with diseases only when the change was=20
>> inherited from a particular parent

and they give examples where certain genetics snippets may be harmful=20
or helpful depending on whether they come from the mother or father;=20
in fact, some can help if from one but harm if from the other.


All this speaks even more to the essential importance of careful=20
tracing of all of the offspring if possible, something breeders=20
should aim for doing to the very best of their ability (and those who=20
buy their ferrets need to help with health data).

This may be such a basic thing physiologically that it could well=20
apply to ferrets for some of the problems to which they are=20
susceptible. For example (with no data and not even guessing but=20
just an illustration why this data might be important using a name=20
just to make it the example more accessible for understanding), maybe=20
offspring are more susceptible to insulinoma (or something else) down=20
the line if the parent of a given gender (just say the father in this=20
example) is from a line that has the problem but not if the other=20
parent (just say the mother in this example) is. Get it? It's not=20
enough to know what the lines have shown, but you have to also know=20
WHICH line. If the previous -- completely fictional -- example is=20
correct, let's say, then it would matter more for insulinoma if the=20
father's line had a genetic susceptibility than if the mother's line=20
did. (Making it more complicated, in some of the things studied in=20
humans the SAME snippets could reduce vulnerability if they came from=20
one side of the family but increase the vulnerability if inherited=20
from the other side of the family.

No one knows why could be -- yet.

Sukie (not a vet)

Recommended ferret health links:
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