From:
Sukie Crandall
Date: 2009-01-09 19:56:44 UTC
Subject: [ferrethealth] recent abstracts (and in one case title wihtout abstract available)
To: fhl <ferrethealth@yahoogroups.com>
BEGIN QUOTES
J Vet Med Sci. 2008 Dec;70(12):1323-6.
Adrenal diseases in ferrets in Japan.
Miwa Y, Nakata M, Kurosawa A, Sasai H, Sasaki N.
Veterinary Surgery, Graduate School of Agricultural and Life Sciences,=20
The University of Tokyo.
Adrenal diseases are quite common in Japanese pet ferrets; however,=20
there have been no reports concerning the epidemiology of ferret=20
adrenal disease in Japan. The purpose of this study was to collect=20
epidemiological data on ferret adrenal disease in Japan by sending a=20
questionnaire to veterinarians throughout Japan. Among the 521 cases=20
that met the criteria for this study, 307 were adrenocortical=20
carcinoma (58.9%), 117 were adrenocortical adenoma (22.5%) and 87 were=20
adrenocortical hyperplasia (16.7%), respectively. Sex, clinical signs,=20
concurrent diseases, age and the sites of the affected adrenal gland=20
in these cases were similar to those reported in North America. Most=20
pet ferrets in Japan are imported from North America, and their=20
husbandry in Japan is similar to that in North America, which may be=20
the cause of the similarity in ferret adrenal disease between North=20
America and Japan. Because a difference in the incidence of ferret=20
adrenal diseases among countries has been reported, further research=20
is necessary to investigate the factors related to the similarities=20
and how to decrease the incidence of adrenal diseases in ferrets in=20
Japan.
PMID: 19122398
Masui. 2008 Dec;57(12):1472-84.
[Curve-fits with hybrid logistic functions for isovolumic left=20
ventricular pressure curve and isometric myocardial tension curve]
[Article in Japanese]
Mizuno J, Morita S, Araki J, Otsuji M, Hanaoka K, Kurihara S.
Department of Anesthesiology, Teikyo University School of Medicine,=20
Tokyo 173-8605 y School of Medicine, Tokyo 105-8461.
Non-linear regression and curve-fitting may contribute to resolution=20
of the mechanism, summarise information, remove noise, allow=20
speculation regarding unmeasured data, and separate the effects of=20
multiple factors. The isovolumic left ventricular (LV) pressure curve=20
and isometric myocardial tension curve have been curve-fit with=20
polynomial expotential and sinusoidal functions. The isovolumic LV=20
pressure curve and myocardial isometric tension curve are composed of=20
contraction and relaxation processes. We have proposed that hybrid=20
logistic (HL) functions, calculated as the difference between two=20
logistic functions, fit better the isovolumic LV pressure curves at=20
any LV volume, heart rate, and infused calcium (Ca2+) concentration in=20
coronary artery in the excised, cross-circulated canine heart, and the=20
isometric twitch tension curves at any muscle length and extracellular=20
Ca2+ concentration in the ferret right ventricular (RV) papillary=20
muscle. We suggest that the six HL parameters are useful to evaluate=20
the contraction and relaxation processes in the heart and myocardium.=20
This HL approach for the isovolumic LV pressure curves and the=20
isometric twitch tension curves may provide a more useful model for=20
speculating Ca2+ handling, Ca(2+) -Troponin C interaction, and cross-
bridge cycling.
PMID: 19108490
Lab Anim (NY). 2009 Jan;38(1):9.
Pelvic limb lameness in a ferret.
Pignon C, Jardel N.
Alfort French National Veterinary School, 7 Avenue du G=E9n=E9ral de=20
Gaulle, 94700 Maisons-Alfort, France.
PMID: 19112443
Proc Natl Acad Sci U S A. 2008 Dec 29. [Epub ahead of print]
Viral RNA polymerase complex promotes optimal growth of 1918 virus in=20
the lower respiratory tract of ferrets.
Watanabe T, Watanabe S, Shinya K, Hyun Kim J, Hatta M, Kawaoka Y.
Department of Pathobiological Sciences, School of Veterinary Medicine,=20
University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706;
The 1918 influenza pandemic was the most devastating outbreak of=20
infectious disease in human history, accounting for about 50 million=20
deaths worldwide. In addition to a significant number of cases of=20
secondary bacterial pneumonia, this highly pathogenic strain of=20
influenza A virus caused fatal primary viral pneumonia. To identify=20
the viral gene(s) chiefly responsible for the high virulence of the=20
1918 virus, we generated a series of reassortants between the 1918=20
virus and a contemporary human H1N1 virus (A/Kawasaki/173/2001; K173)=20
using reverse genetics. We then assessed their virulence properties in=20
ferrets, a model closely resembling humans in terms of sensitivity to=20
influenza virus infection and pattern of spread after intranasal=20
inoculation. Substitution of single genes from the 1918 virus in the=20
genetic background of K173 virus did not markedly alter the pattern of=20
infection. That is, the reassortants grew well in nasal turbinates,=20
but only sporadically (if at all) in the trachea and lungs. One=20
exception was the 1918PB1/K173 reassortant, which replicated=20
efficiently in lung tissues as well as the upper respiratory tract. A=20
reassortant virus expressing the 1918 viral RNA polymerase complex=20
(PA, PB1, and PB2) and nucleoprotein showed virulence properties in=20
the upper and lower respiratory tracts of ferrets that closely=20
resembled those of wild-type 1918 virus. Our findings strongly=20
implicate the viral RNA polymerase complex as a major determinant of=20
the pathogenicity of the 1918 pandemic virus. This new insight may aid=20
in identifying virulence factors in future pandemic viruses that could=20
be targeted with antiviral compounds.
PMID: 19114663
END QUOTED ABSTRACTS
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
[Non-text portions of this message have been removed]
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