From:
Sukie Crandall
Date: 2009-01-13 20:02:18 UTC
Subject: [ferrethealth] new ferret abstracts
To: fhl <ferrethealth@yahoogroups.com>
AVOID the use of any VapoRub or menthol approaches for anything with a=20
narrow trachea, including ferrets and young children. The sensation=20
of cold that it gives may *feel* like it is giving comfort but the=20
reality is that it worsens the health situation.
There are a great many news stories on this. The press release=20
appeared earlier.
The abstract just became available:
http://www.ncbi.nlm.nih.gov/pubmed/19136404
BEGIN QUOTED ABSTRACT
Chest. 2009 Jan;135(1):143-8.
Vicks VapoRub Induces Mucin Secretion, Decreases Ciliary Beat=20
Frequency, and Increases Tracheal Mucus Transport in the Ferret Trachea.
Abanses JC, Arima S, Rubin BK.
Department of Pediatrics, Wake Forest University School of Medicine,=20
Medical Center Blvd, Winston-Salem, NC 27157-1081.
BACKGROUND: Vicks VapoRub (VVR) [Proctor and Gamble; Cincinnati, OH]=20
is often used to relieve symptoms of chest congestion. We cared for a=20
toddler in whom severe respiratory distress developed after VVR was=20
applied directly under her nose. We hypothesized that VVR induced=20
inflammation and adversely affected mucociliary function, and tested=20
this hypothesis in an animal model of airway inflammation. METHODS:=20
[1] Trachea specimens excised from 15 healthy ferrets were incubated=20
in culture plates lined with 200 mg of VVR, and the mucin secretion=20
was compared to those from controls without VVR. Tracheal mucociliary=20
transport velocity (MCTV) was measured by timing the movement of 4 muL=20
of mucus across the trachea. Ciliary beat frequency (CBF) was measured=20
using video microscopy. [2] Anesthetized and intubated ferrets inhaled=20
a placebo or VVR that was placed at the proximal end of the=20
endotracheal tube. We evaluated both healthy ferrets and animals in=20
which we first induced tracheal inflammation with bacterial endotoxin=20
(a lipopolysaccharide [LPS]). Mucin secretion was measured using an=20
enzyme-linked lectin assay, and lung water was measured by wet/dry=20
weight ratios. RESULTS: [1] Mucin secretion was increased by 63% over=20
the controls in the VVR in vitro group (p < 0.01). CBF was decreased=20
by 35% (p < 0.05) in the VVR group. [2] Neither LPS nor VVR increased=20
lung water, but LPS decreased MCTV in both normal airways (31%) and=20
VVR-exposed airways (30%; p =3D 0.03), and VVR increased MCTV by 34% in =
LPS-inflamed airways (p =3D 0.002). CONCLUSIONS: VVR stimulates mucin=20
secretion and MCTV in the LPS-inflamed ferret airway. This set of=20
findings is similar to the acute inflammatory stimulation observed=20
with exposure to irritants, and may lead to mucus obstruction of small=20
airways and increased nasal resistance.
PMID: 19136404
END QUOTED ABSTRACT
Hey, live and learn. We used to use this stiff as kids and I am sure=20
many use it because it tricks the body into thinking that it is more=20
comfortable which may not be a problem for healthy larger mammals, but=20
for small ones trading the chance of feeling a bit better with the=20
reality of risking acute respiratory risks just does not make sense. =
Best to keep it far away from small mammals.
http://www.ncbi.nlm.nih.gov/pubmed/19137538
BEGIN QUOTED ABSTRACT
J Exp Zoolog B Mol Dev Evol. 2009 Jan 9. [Epub ahead of print]
The role of the dental lamina in mammalian tooth replacement.
J=E4rvinen E, Tummers M, Thesleff I.
Developmental Biology Program, Institute of Biotechnology, Viikki=20
Biocenter, University of Helsinki, Helsinki, Finland.
We have applied the ferret, Mustela putorius furo, as a model for=20
tooth replacement. Ferret has a heterodont dentition, which includes=20
all tooth families, and all antemolar teeth are replaced. Compared=20
with mouse, the ferret therefore has a less derived mammalian=20
dentition resembling that of humans. We have studied tooth replacement=20
in serial histological sections in embryonic and young postnatal=20
ferrets. Our observations indicate that the replacement teeth form=20
from the dental lamina that is intimately connected to the lingual=20
aspect of the deciduous tooth enamel organ. It grows as an offshoot=20
from the enamel organ, elongates in cervical direction and later buds=20
to give rise to the replacement tooth. The extent of the dental lamina=20
growth, preceding replacement tooth budding, varied between different=20
teeth. The dynamic gene expression patterns of Sostdc1, Shh and Axin2=20
brought new insight into the signal networks regulating the tooth=20
replacement process. The distinct expression of Sostdc1 at the=20
interface between the dental lamina and the deciduous tooth is the=20
first indication of a specific tissue identity of the dental lamina.=20
We suggest that the reactivation of a competent dental lamina is=20
pivotal for the replacement tooth formation. J. Exp. Zool. (Mol. Dev.=20
Evol.) 312B, 2009. (c) 2009 Wiley-Liss, Inc.
PMID: 19137538
END QUOTED ABSTRACT
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
[Non-text portions of this message have been removed]
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