From:
Sukie Crandall
Date: 2009-01-16 18:18:17 UTC
Subject: [ferrethealth] abstracts (and one may raise your eyebrows for more than one reason)
To: fhl <ferrethealth@yahoogroups.com>
http://www.ncbi.nlm.nih.gov/pubmed/19144866
> Exp Biol Med (Maywood). 2009 Jan 14. [Epub ahead of print]
> Fatty acid composition and development of hepatic lipidosis during=20
> food deprivation - mustelids as a potential animal model for liver=20
> steatosis.
>
> Nieminen P, Mustonen AM, K=E4rj=E4 V, Asikainen J, Rouvinen-Watt K.
> Univ of Joensuu.
> Non-alcoholic fatty liver disease (NAFLD) is the hepatic=20
> manifestation of the metabolic syndrome characterized by=20
> asymptomatic hepatic lipidosis. It is present in most cases of human=20
> obesity but also caused e.g. by rapid weight loss. The patients have=20
> decreased n-3 polyunsaturated fatty acid (PUFA) proportions with=20
> decreased percentages of 18:3(n-3), 20:5(n-3) and 22:6(n-3) and an=20
> increased n-6/n-3 PUFA ratio in liver and/or white adipose tissue=20
> (WAT). The present study examined a new experimental model to study=20
> liver steatosis with possible future applications to NAFLD. Ten=20
> European polecats (Mustela putorius), the wild form of the domestic=20
> ferret, were food-deprived for 5 d with 10 fed animals as controls.=20
> The food-deprived animals showed micro- and macrovesicular hepatic=20
> lipidosis, decreased proportions of 20:5(n-3), 22:6(n-3) and total=20
> n-3 PUFA and increased n-6/n-3 PUFA ratios in liver and WAT. At the=20
> same time, the product/precursor ratios decreased in liver. The=20
> observed effects can be due to selective fatty acid mobilization=20
> preferring n-3 PUFA over n-6 PUFA, decreased Delta5 and Delta6=20
> desaturase activities, oxidative stress, decreased arginine=20
> availability and activation of the endocannabinoid system. Hepatic=20
> lipidosis induced by food deprivation was manifested in the fatty=20
> acid composition of the polecat with similarities to human NAFLD=20
> despite of the different principal etiologies.
> PMID: 19144866
http://www.ncbi.nlm.nih.gov/pubmed/19144625
> Vet Pathol. 2009 Jan 13. [Epub ahead of print]
> Alcian Blue and Pyronine Y histochemical stains permit assessment of=20
> multiple parameters in pulmonary disease models.
>
> Meyerholz D, Rodgers J, Castilow E, Varga S.
> UI Carver College of Medicine, 145 MRC, Iowa City, Iowa, 52242,=20
> United States of America.
> Utilization of a combined Alcian Blue and Pyronine Y histochemical=20
> method for the assessment of multiple parameters in the respiratory=20
> tract of various species is described. Acidic mucins were deep blue=20
> (sialylated mucins), red (sulfated mucins), or variably purple=20
> (mixture of sialylated/sulfated mucins), and differential mucus=20
> production was readily detected in a murine respiratory syncytial=20
> virus vaccine model of pulmonary inflammation. Elastic fibers=20
> stained red in the walls of pulmonary arteries, connecting airways,=20
> alveolar septa, and subpleural interstitium. Mast cells had red to=20
> red-purple granular cytoplasmic staining. Nuclei were ubiquitously=20
> counterstained pale blue. Representative staining was detected in=20
> tissues from multiple species including inbred mice, rats, ferrets,=20
> cats, dogs, sheep, and pigs. The fluorescent property of the stained=20
> tissues offers additional modalities with which to analyze tissue=20
> sections. This histochemical technique detects multiple critical=20
> parameters in routine paraffin sections of lung tissue, reduces the=20
> need for repeated serial sectioning and staining, and is cost-
> effective and simple to perform.
> PMID: 19144625
[Non-text portions of this message have been removed]
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