From:
"Sukie Crandall"
Date: 2009-01-25 01:25:02 UTC
Subject: [ferrethealth] Re: behavioral health change achieved w oil
To: ferrethealth@yahoogroups.com
Ah, after several empty searches earlier i suddenly thought
of the right term combo
Now this is a human article, but many cultures speak
of letting animals lick wounds to heal them so the
mechanism may be the same.
I recall when I had to have surgery to remove a lesion
from my tongue the surgeon said not to worry that
the stitches pulled out in hours because tongues
almost never get infected and it was thought to be
from the constant bathing by a factor in saliva.
http://www.fasebj.org/cgi/content/full/22/11/3805
to get full article
http://www.ncbi.nlm.nih.gov/pubmed/18650243
BEGIN QUOTE
FASEB J. 2008 Nov;22(11):3805-12. Epub 2008 Jul 23.
Histatins are the major wound-closure stimulating
factors in human saliva as identified in a cell culture assay.
Oudhoff MJ, Bolscher JG, Nazmi K, Kalay H, van 't Hof W,
Amerongen AV, Veerman EC.
Academic Centre for Dentistry Amsterdam, University of
Amsterdam and VU University Amsterdam, Department of
Oral Biochemistry, Van der Boechorststraat 7, 1081 BT
Amsterdam, The Netherlands.
Wounds in the oral cavity heal much faster than skin lesions.
Among other factors, saliva is generally assumed to be of
relevance to this feature. Rodent saliva contains large
amounts of growth factors such as epidermal growth factor
(EGF) and nerve growth factor (NGF). In humans, however,
the identity of the involved compounds has remained elusive,
especially since EGF and NGF concentrations are approximately
100,000 times lower than those in rodent saliva. Using an in
vitro model for wound closure, we examined the properties of
human saliva and the fractions that were obtained from saliva
by high-performance liquid chromotography (HPLC) separation.
We identified histatin 1 (Hst1) and histatin 2 (Hst2) as major
wound-closing factors in human saliva. In contrast, the
d-enantiomer of Hst2 did not induce wound closure, indicating
stereospecific activation. Furthermore, histatins were actively
internalized by epithelial cells and specifically used the extracellular
signal-regulated kinases 1/2 (ERK1/2) pathway, thereby
enhancing epithelial migration. This study demonstrates that
members of the histatin family, which up to now were implicated
in the antifungal weaponry of saliva, exert a novel function that
likely is relevant for oral wound healing.
PMID: 18650243
END QUOTE
I'll periodically see if I can find something even closer to home if I think
of some other term combos for searches.
Histatins can also be anti-virals:
http://www.ncbi.nlm.nih.gov/pubmed/19040288
On the other hand, sometimes the OPPOSITE can result:
http://www.ncbi.nlm.nih.gov/pubmed/18566152
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