From:
"Amanda"
Date: 2009-02-04 19:20:32 UTC
Subject: [ferrethealth] Re: Lupron dosage, sources and storage (Corrections to my previous post)
To: ferrethealth@yahoogroups.com
I realize now that I tend to think faster than I can type so things
come out in the wrong order. Please note the following corrections to
my previous post...
I mixed up 3 and 4 mon when describing how best results are observed.
It should have read "4 mon depot injections every 3 mon" oops!
--- In ferrethealth@yahoogroups.com, "Amanda" <amandadegraw@...> wrote:
>
> I am a chemist that works on creating pharmaceutical formulations like
> this, so hopefully I can explain this well enough...
>
> As previously mentioned, depot formulation means is releases drug over
> time. 1 mon depot = releases drug for one mon, 3 mon = releases drug
> over 3 mon. As previously guessed, there is an initial "burst" of drug
> released from the depot when administered and it is quite possible
> that with the longer depot formulations, there is a bigger burst. It
> is critical that everyone understand the way Lupron works, as that
> will help people understand why the longer formulations may give what
> appears to be better results. Lupron is an LHRH agonist. These means
> it actually causes the body to release MORE hormone initially. It is
> this "flood of information" that actually causes the body to stop
> producing the hormone. So,if we look at the 1 mon formulation, this
> means in that first week there is a done of hormone present, so you
> will not see much of an effect. You may even seen the opposite. But,
> after that initial flood of hormones, your body stops producing them,
> so you will see an effect. Meanwhile, the depot is still releasing
> drug so your body will continue to scale back its hormone production.
> If the amount of drug in the system falls below a certain threshold,
> then the body will start producing the hormone again. So, with a 1 mon
> depot, you need an injection every mon, on a VERY timely basis to
> prevent the body starting up. With a longer depot formulation, the
> drug being released stays above that threshold for a longer period of
> time, thus putting off the injections to say every 3 mon or 4 mon.
> Again, re-injection before the drug drops below that threshold is
> critical.
>
> So, if you are still following me here, people may see the "best"
> results with a 3 mon depot being injected every 4 mon because it keeps
> the body from ever dropping below that critical threshold.If one
> wanted to achieve the same effect with a 1 mon depot, it should be
> given every 3 wks instead of 4-5 weeks (which I am sure given time and
> money, that is usually what happens with people).
>
> I hope that all made sense. Feel free to email me directly if you have
> more questions. I love talking pharmaceutical chemistry! And I love
> ferrets, so I guess I can be of service. :)
>
> regards,
> Amanda and her Izzy B
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