From:
Sukie Crandall
Date: 2009-03-02 19:48:16 UTC
Subject: [ferrethealth] when anastrozole/Arimidex can be useful and when not
To: fhl <ferrethealth@yahoogroups.com>, ferret-l@LISTSERV.FERRETMAILINGLIST.ORG
Anastrozole (Arimidex) came up in something today
so I decided to look it up in case others can also use
having more details at their fingertips.
These have info:
http://www.hofa-rescue.org/health/documents/illness/Melatonin.pdf
includes:
BEGIN SHORT QUOTES
[Melatonin] is safe to use in combination with other adrenal
medicines such as leuprolide acetate (Lupron depot),
finasteride (Propecia or Proscar) and anastrozole
(Arimidex) ...
Anastrozole, such as Arimidex, is a tablet
that can be used to treat estrogen-induced
anemia, thrombocytopenia and mammary
gland hyperplasia. This product is an enzyme
inhibitor that stops the formation of estrogen.
After the estrogen level is lowered, the bone
marrow can start making red blood cells and
platelets again. The suggested dose is one
tenth of a milligram per kilogram once a day.
END SHORT QUOTES
(There are over a hundred studies in various species
including many in ferrets for human medicine information
which place or help place persistent high levels of LH at the
root of adrenal neoplasia, but ferrets without gonads can
not signal the pituitary to reduce LH output. LH output
increases in response to more light exposure causing
decreases in the natural levels of melatonin that the body's
pineal gland produces in darkness. Things get added to
the body of knowledge over time.)
http://www.vet.uga.edu/vpp/clerk/johnson/index.php
> Anastrozole (Arimidex, Zeneca Pharmaceuticals, Wilmington, DE) is an
> aromatase inhibitor that inhibits the production of estrone and
> estradiol from their precursor molecules.8 Ferrets often have
> increased concentrations of several different sex hormones in
> addition to or independently of estrogen. In these affected
> individuals, anastrozole is ineffective. This drug is relatively
> expensive and, therefore, is not commonly used to treat adrenal
> disease in ferrets.
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
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