From:
Sukie Crandall
Date: 2009-03-18 18:14:27 UTC
Subject: [ferrethealth] abstract
To: fhl <ferrethealth@yahoogroups.com>
ferret kit brain development
> Pediatr Res. 2009 Mar 12. [Epub ahead of print]
> Characterization of Brain Development in the Ferret via Magnetic
> Resonance Imaging.
>
> Barnette AR, Neil JJ, Kroenke CD, Griffith JL, Epstein AA, Bayly
> PV,Knutsen AK, Inder TE.
> Department of Pediatrics [A.R.B., J.J.N., T.E.I.], Mallinckrodt
> Institute of Radiology [J.J.N., J.L.G., A.A.E., P.V.B., A.K.K.,
> T.E.I.], Department of Neurology [J.J.N., T.E.I.], Washington
> University, St. Louis, MO, 63110; Department of Behavioral
> Neuroscience [C.D.K.], Oregon Health and Science University,
> Portland, OR, 97239; Department of Mechanical Engineering [P.V.B.,
> A.K.K.], Washington University, St. Louis, MO 63105.
>
> Animal models with complex cortical development are useful for
> improving our understanding of the wide spectrum of
> neurodevelopmental challenges facing human preterm infants. Magnetic
> resonance imaging (MRI) techniques can define both cerebral injury
> and alterations in cerebral development with translation between
> animal models and the human infant. We hypothesized that the
> immature ferret would display a similar sequence of brain
> development (both grey (GM) and white matter (WM)) to that of the
> preterm human infant. We describe postnatal ferret neurodevelopment
> with conventional and diffusion MRI. The ferret is born
> lissencephalic with a thin cortical plate and relatively large
> ventricles. Cortical folding and WM maturation take place during the
> first month of life. From the mid-second through the third week of
> postnatal life, the ferret brain undergoes a similar, though less
> complex, pattern of maturational changes to those observed in the
> human brain during the second half of gestation. GM anisotropy
> decreases rapidly in the first three weeks of life, followed by an
> upward surge of surface folding and WM anisotropy over the next two
> weeks.
> PMID: 19287340
[Non-text portions of this message have been removed]
------------------------------------
Yahoo! Groups Links
<*> To visit your group on the web, go to:
http://groups.yahoo.com/group/ferrethealth/
<*> Your email settings:
Individual Email | Traditional
<*> To change settings online go to:
http://groups.yahoo.com/group/ferrethealth/join
(Yahoo! ID required)
<*> To change settings via email:
mailto:ferrethealth-digest@yahoogroups.com
mailto:ferrethealth-fullfeatured@yahoogroups.com
<*> To unsubscribe from this group, send an email to:
ferrethealth-unsubscribe@yahoogroups.com
<*> Your use of Yahoo! Groups is subject to:
http://docs.yahoo.com/info/terms/