From:
Sukie Crandall
Date: 2009-03-25 19:21:07 UTC
Subject: [ferrethealth] Re: thinking about types of adrenal growths that don't behave like adrenal
To: fhl <ferrethealth@yahoogroups.com>
BTW, apologies for the FHL being up and down. Yahoo is moving all
Yahoogrooups to new servers.
I was lucky enough to learn from a friend who is researcher about some
other types of rare adrenal tumors that can have negative TN Panels.
Again, we are talking very rare, but Steve and I have one for whom
such tumor types have to be considered so we are learning to cautions
beforehand to best help her and our vets. Her exploratory will be
Monday.
Even if these don't help us they may help others.
Pheochromocytoma can behave that way. I already included info on
Teratomas and Tressie linked to a study on those.
I found this reference but can not open it. It looks like extra heart
caution is needed with one possibility but I can't open it to see if
location matters:
> Ferret Cardiology - Elsevier
> Clinical presentation of cardiac disease in the ferret ranges from
> an ..... Functionalpheochromocytomas can cause sinus tachycardia,
> hypertension, ...
> linkinghub.elsevier.com/retrieve/pii/S1094919408000613 - Similar pages
> by RA Wagner - 2008 - Related articles - All 3 versions
http://www.aemv.org/Documents/2006_AEMV_proceedings_10.pdf
includes
BEGIN QUOTE
There are 3 currently accepted human familial syndromes in which
there is a progression from
hyperplasia to neoplasia in endocrine tissues; these include MEN types
1 (MEN1), 2a (MEN2a), and 2b (MEN2b).
MEN1 syndrome usually is characterized by parathyroid hyperplasia,
pancreatic islet cell, and/or pituitary tumors.
Up to 40% of MEN1 patients also develop adrenal, thyroid, or thymic
tissue tumors. MEN2a and MEN2b syndromes
are characterized primarily as medullary thyroid cancer (MTC) with or
without pheochromocytomas and parathyroid
adenomas. MEN1 and MEN2 are inherited as autosomal-dominant genetic
traits.
END QUOTE
Page 308 of _Rabbit and Ferret Laboratory Medicine_:
<http://books.google.com/books?id=TGZ8nYBqH9sC&pg=PA308&lpg=PA308&dq=pheochromocytomas+%2Bferret&source=bl&ots=Fp9UaeyENo&sig=6RzTFSe8NNpk4skxc96ejVlqZak&hl=en&ei=53zKSb26N4HnnQe32riNAw&sa=X&oi=book_result&resnum=4&ct=result
>
description includes: rare, aggressive, space-occupying, usually
nonfunctional "although Brown reports one case with TACHYCARDIA", will
invade the Cava and other nearby structures, difficulty removing, one
had complete resection, histochemical strains or electron microscopy
are needed to tell it from adrenocortical carcinoma by spotting
characteristic secretory granules, TEST URINE FOR CATECHOLAMINES
(usually need to use a human or comparative endocrinology lab)
Luckily, her problem has been going on long enough that an aggressive
growth like this is going to be much less likely.
http://www.vetpathology.org/cgi/content/full/37/3/278
is
> C-Cell Carcinoma (Medullary Thyroid Carcinoma) Associated with
> Multiple Endocrine Neoplasms in a Ferret (Mustela putorius)
Unusual (and usual) ultrasound results:
http://www.advetds.com/graphics/ferret.pdf
Mentioned briefly in __Biology and Diseases of the Ferret_
I have to dig into a Fox study on non-secretory adrenal tumors, but
first i have to find it.
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
[Non-text portions of this message have been removed]
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