From:
"Karen McCabe"
Date: 2009-05-06 01:14:02 UTC
Subject: [ferrethealth] Re:Melatonin question
To: ferrethealth@yahoogroups.com
--- In ferrethealth@yahoogroups.com, AFERRETVET@... wrote:
>
> Hi Karen
> I'll give you the adverse effects listed in the melatonin
> article that was peer reviewed and in the Journal of the
> American Veterinary Medical Association: "...adverse
> effects associated with long-term use of melatonin, which
> are generally restricted to inhibition of reproductive function,
> delay of puberty, and influence on circadian status of fetus
> or neonate if the recipient is pregnant or lactating."
I'm not familiar with this article. Can anyone tell me where I might find it in it's entirety? I'm searching but not having much luck.
> Somnolence (sleepiness) is a common side effect from
> melatonin like Dr Ruth points out, but it usually only last
> 2-5 days and not to the extreme that Cathy described.
> Therefore kidney damage from ketamine in a senior patient is
> a more likely cause for the extreme lethargy that she described.
Perhaps, though Dr. Delaney does state that "no physical or medical reason for the lethargy could be found".
> BTW There was also a study done in New Zealand with 3 month
> old ferret kits. They were giving an 8 mg melatonin implant
> (roughly 1.5 times the amount of the 5.4 mg ferret implant)
> at 3 months of age and again 12 months later. No adverse
> reactions were reported during that 16 month study (Seasonal
> fiber growth cycles of ferrets (Mustela putorius furo) and long term
> effects of melatonin treatment.)
I'll have to see if I can find this article as well.
Thank you for your time Dr. Murray, it is appreciated.
Karen McCabe
http://www.cinnamonsprite.net
[Moderator's Note:
Remember that in ferrets kidney damage commonly
does NOT show up on tests until it is advanced, so
kidney damage could happen without it being readily
discernible. The study would have been better done
with a gas anesthesia to remove the possible complications
of injected ketamine. Hey, next time...]
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