From:
Sukie Crandall
Date: 2009-05-10 05:09:44 UTC
Subject: [ferrethealth] abstracts
To: fhl <ferrethealth@yahoogroups.com>
Notice that the percentages are of the total number of reported
neoplasia and NOT the rates in the general ferret population (which
simply don't exist for most to all of these form of growths).
BEGIN QUOTE
Neoplasitic diseases in ferrets in Japan: a questionnaire study for
2000 to 2005.
Miwa Y, Kurosawa A, Ogawa H, Nakayama H, Sasai H, Sasaki N.
Laboratory of Veterinary Emergency Medicine, Graduate School of
Agricultural and Life Sciences, The University of Tokyo.
The objective of this study was to collect epidemiological data on
neoplasms in pet ferrets in Japan. A questionnaire to collect
information was made available to Japanese veterinary practitioners
through the web site of the Japanese Society of Exotic Pet Medicine.
Completed questionnaires were returned from 29 practices, and 945
neoplasms met the criteria for inclusion in the study. Neoplasms were
found in every organ system except the respiratory system; the
endocrine (418; 44.2%), integumentary (196; 20.7%) and hemolymphatic
(184; 19.5%) systems were most commonly affected. The most common
tumor types were pancreatic islet cell tumor (211: 22.3%), adrenal
gland tumor (207; 21.9%) and lymphoma (152; 16.1%). The age of the
affected ferrets ranged from less than 3 months to more than 7 years
of age. Tumor incidence was highest in ferrets between 4 and 6 years
of age. No sex predilection was found. These results were similar to
those recently published in North America. Most Japanese pet ferrets
are imported from North America, and their husbandry including diets
is similar to that in North America, which may explain the similar
tendencies in the incidence of neoplasms in this study and those of
findings in North America.
PMID: 19420840
END QUOTE
endocrinological effects of a pollutant on the cousin, the mink:
BEGIN QUOTE
Reproductive and developmental toxicity of a pentabrominated diphenyl
ether mixture, DE-71(R), to ranch mink (Mustela vison) and hazard
assessment for wild mink in the Great Lakes region.
Zhang S, Bursian SJ, Martin PA, Chan HM, Tomy G, Palace VP,Mayne GJ,
Martin JW.
Department of Laboratory Medicine and Pathology, University of
Alberta, Edmonton, Alberta, Canada, T6G 2G3
Polybrominated diphenyl ethers (PBDEs) are widespread persistent and
bioaccumulative environmental contaminants. Recent scientific
attention has focused on the developmental toxicity of PBDE commercial
mixtures following perinatal exposure of rodents, however these
studies do not necessarily predict toxicity to highly exposed top
predators, such as mink (Mustela vison). Here we assessed the effects
of environmentally relevant doses (0, 0.1, 0.5 and 2.5 parts-per-
million (ppm, w/w) in feed) of a technical penta-BDE mixture,
DE-71((R)), on reproductive performance of mink and on development of
offspring exposed perinatally and post-weaning until 33 weeks. A
dietary concentration that causes no effects on reproduction in
rodents, 2.5 ppm DE-71((R)), resulted in complete reproductive failure
in these mink, while whelping rates were not affected at all lower
does. Developmental effects in offspring were evident in 33-week old
juveniles, which were more sensitive to effects than their respective
dams. Juvenile thyroid hormone homeostasis was also much more
sensitive compared to rodents, and at 0.5 ppm DE-71((R)) total
triiodothyronine (T3) was significantly decreased in all males and
females, even despite a compensatory decrease of total thyroxine (T4)
in females. T4-outer ring deiodinase (T4-ORD) activity, mainly
contributed by Type II deiodinase, was not affected at any dose for
any life stage, but thyroid follicular epithelium cell height was
elevated in the 0.5 ppm treated juveniles (p = 0.057). Ethoxy-
resorufin O-deethylase (EROD) activity was significantly induced in
all offspring at 33 weeks, most likely as a consequence of
polybrominated dioxin, furan, or biphenyl impurities in DE-71.
Biomonitoring of wild mink in the Great Lakes region indicated that
most populations had lower concentrations than what are expected to
affect thyroid hormone homeostasis, but margins of safety are small
and mink around Hamilton Harbour exceeded the NOAEL for T3 disruption.
PMID: 19420013
END QUOTE
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
[Non-text portions of this message have been removed]
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