From:
Sukie Crandall
Date: 2009-05-12 19:11:43 UTC
Subject: [ferrethealth] Abstracts
To: fhl <ferrethealth@yahoogroups.com>
The first by:
http://www.ferrethealth.msu.edu/
Vet Pathol. 2009 May 9. [Epub ahead of print]
Detection of Group C Rotavirus in Juvenile Ferrets (<I>Mustela
putorius furo</I>)with Diarrhea by Reverse Transcription Polymerase
Chain Reaction: Sequencing and Analysis of the Complete Coding Region
of the VP6 Gene.
Wise A, Smedley R, Kiupel M, Maes R.
East Lansing, 48910, United States of America.
Nine juvenile ferrets (Mustela putorius furo) with a history of
diarrhea were severely dehydrated, had distended abdomens, and thin-
walled small intestines that contained gas and fluid. Histologically,
small intestines exhibited acute superficial atrophic enteritis.
Transmission electron microscopy of the small intestine showed
rotavirus-like particles within apical vacuoles. RT-PCR was negative
for group A rotavirus. A group C rotavirus-specific RT-PCR assay was
developed using consensus primers designed from the alignment of VP6
gene sequences of porcine, bovine and human strains. A 182-bp product
of the VP6 gene was sequenced and showed significant similarity to
group C rotavirus VP6 sequences. This strain was designated "Ferret
Rota C-MSU". The entire coding sequence of VP6 was determined and
compared with other rotaviruses. Ferret Rota C-MSU virus was found to
be most closely related to Shintoku group C rotavirus. This is the
first definitive identification of a group C rotavirus in ferrets,
based upon RT-PCR, sequencing and genetic analysis.
PMID: 19429992
This is work by:
http://www.ferrethealth.msu.edu/
---
Behav Brain Res. 2009 Jul 19;201(1):233-6. Epub 2009 Feb 23.
Paradoxical effects of the hypnotic Zolpidem in the neonatal ferret.
Hsu N, Jha SK, Coleman T, Frank MG.
Department of Neuroscience, University of Pennsylvania School of
Medicine, Philadelphia, PA 19104, USA.
Hypnotic drugs designed to treat insomnia in adults are now
increasingly used in children, but the effects of these compounds on
neonatal sleep are poorly understood. We investigated the hypnotic
effects of the commonly prescribed non-benzodiazepine sleep agent
Zolpidem (Ambien) on sleep architecture and electroencephalographic
(EEG) activity in the neonatal ferret. Six ferret kits were surgically
prepared for EEG/electromyographic (EMG) recordings using techniques
adopted for use in neonatal animals. They were then administered in a
counter-balanced design vehicle, or Zolpidem (2 mg/kg or 20 mg/kg) via
intraperitoneal injection (1x/day over three days at 1 p.m.). Zolpidem
did not increase non-rapid-eye-movement (NREM) or total sleep time.
Instead Zolpidem reduced REM sleep and total sleep amounts and
increased NREM sleep bout duration. Zolpidem also increased higher-
frequency EEG energies during REM and NREM sleep and transiently
produced a behavioral state that appeared intermediate between wake
and sleep. Our findings demonstrate that hypnotics that improve sleep
quality in adults may produce profoundly different behavioral changes
in neonates.
PMID: 19428639
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
[Non-text portions of this message have been removed]
------------------------------------
Yahoo! Groups Links
<*> To visit your group on the web, go to:
http://groups.yahoo.com/group/ferrethealth/
<*> Your email settings:
Individual Email | Traditional
<*> To change settings online go to:
http://groups.yahoo.com/group/ferrethealth/join
(Yahoo! ID required)
<*> To change settings via email:
mailto:ferrethealth-digest@yahoogroups.com
mailto:ferrethealth-fullfeatured@yahoogroups.com
<*> To unsubscribe from this group, send an email to:
ferrethealth-unsubscribe@yahoogroups.com
<*> Your use of Yahoo! Groups is subject to:
http://docs.yahoo.com/info/terms/