From:
"Karen McCabe"
Date: 2009-06-05 06:38:09 UTC
Subject: [ferrethealth] Re: Adrenal Treatments Question
To: ferrethealth@yahoogroups.com
>
> [Moderator Note:
> That particular study involved very few ferrets if memory serves.]
>
References to the number of ferrets involved and time length of studies....
"As 3 month lupron is exorbitantly expensive, and if the 30 day lupron
is fresh, frozen for no more than 1-3 months, and dosages are not
missed, there has been no "refractoriness" to it in the 10 years I have been using this drug in ferrets on a monthly basis. Some ferrets on the study received monthly lupron for nearly 4 years with effectiveness until the tumor was beyond pituitary control. "
"Note: at my clinic and the Washington Ferret Rescue none of our lupron used is over 30 days from mixing and freezing - usually considerably less time. We go through over 150 100 mcg doses a month. We have not seen refractoriness or lack of effectiveness with this drug even used for more than 3 years monthly."
"In Seattle, from 5 years of hormone tracking in intacts, neutered at puberty and early spay/neuter, we didn't need to do it a second time."
"So based on all of the above, 4 years ago we started a small study to do just that: a chemical breeding at the first puberty and then annually block the seasonal stimulation - using lupron 30 day depot formulation. 100 mcg for the females, 200 mcg for the males, delivered intramuscularly. We have over 50 ferrets we have now been doing this with - some are close to 5 years of age, the bulk are 3 years old. We have no adrenal disease in these so far. Time will tell. But we do know that in a group of 50 early spay/neutered ferrets without any intervention - it is likely that several would already have adrenal disease."
"The 6 study early spay/neuter ferrets live at my house and work is continuing following them - 2 are on lupron monthly, all get it annually, but I may have missed that really crucial first puberty time point with them as we didn't know then what was happening with the hormone levels. These ferret's hormones were higher than their age/sex matched intact counterparts! Difference was that the intact ferrets' cycle out as the weather got warmer - the early spay/neuter ferrets stayed high. Time will tell, as it will with the ferrets we are trying the pre-emptive lupron per breeding season."
And there may be other references that I may have missed as well.
It doesn't sound like a small number to me.
Karen McCabe
http://www.cinnamonsprite.net
[Moderator's Question:
It sounds like you are quoting from general observations
from treatment (clinical report rather than study) as well
as her 6 ferret prevention study, and that the quotes are
mostly from the prevention work without adrenal disease
having been present, with just a little from the post-adrenal
disease work, so could you check which studies these
statements are from because those are very different
investigations so mixing them confuses things (if that is
what has happened)?]
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