Message Number: FHL9162 | New FHL Archives Search
From: "Karen McCabe"
Date: 2009-06-05 20:53:30 UTC
Subject: [ferrethealth] Re: Adrenal Treatments Question
To: ferrethealth@yahoogroups.com

> [Moderator's Question:
>
> It sounds like you are quoting from general observations
> from treatment (clinical report rather than study) as well
> as her 6 ferret prevention study, and that the quotes are
> mostly from the prevention work without adrenal disease
> having been present, with just a little from the post-adrenal
> disease work, so could you check which studies these
> statements are from because those are very different
> investigations so mixing them confuses things (if that is
> what has happened)?]
>

I would think the conclusions reached would be based on all experience, rather then just one study, and Dr. Delaney's experience with lupron does appear to be extensive. From that same article....


"Please remember that it was only in September of 1996 that lupron was
first used in a ferret (Robbie McFerret Delaney) with adrenal disease: he died after 11 months with the adrenal disease fully controlled, but due to islet cell carcinoma at age 7.5. After his necropsy and histopathology, I began using lupron on other ferrets and Drs. Susan Orosz, Jack Oliver and myself along with help from the Washington Ferret Rescue & Shelter, and TAP Pharmaceuticals (provided the first study lupron) began the controlled studies."


In any case, the following paragraphs do appear to address cases where adrenal disease was present....


"As 3 month lupron is exorbitantly expensive, and if the 30 day lupron
is fresh, frozen for no more than 1-3 months, and dosages are not
missed, there has been no "refractoriness" to it in the 10 years I have been using this drug in ferrets on a monthly basis. Some ferrets on the study received monthly lupron for nearly 4 years with effectiveness until the tumor was beyond pituitary control. "


"Note: at my clinic and the Washington Ferret Rescue none of our lupron used is over 30 days from mixing and freezing - usually considerably less time. We go through over 150 100 mcg doses a month. We have not seen refractoriness or lack of effectiveness with this drug even used for more than 3 years monthly."


Karen McCabe
http://www.cinnamonsprite.net




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