From:
Sukie Crandall
Date: 2009-06-21 18:06:05 UTC
Subject: [ferrethealth] abstract: a respiratory illness in the UK
To: fhl <ferrethealth@yahoogroups.com>
Mycopathologia. 2009 Jun 16. [Epub ahead of print]
Adiaspiromycosis Due to Emmonsia crescens is Widespread in Native
British Mammals.
Borman AM, Simpson VR, Palmer MD, Linton CJ, Johnson EM.
Mycology Reference Laboratory, Health Protection Agency South West
Regional Laboratory, Myrtle Road, Bristol, BS2 8EL, UK, Andy.Borman@uhBristol.nhs.uk
.
Adiaspiromycosis caused by Emmonsia crescens is primarily a
respiratory disease affecting small mammals, especially members of the
Families Rodentia, Carnivora and Mustelidae. Although isolated reports
exist of adiaspiromycosis in free-living British wildlife, the extent
of infection in wild animals in the UK, and the significance of any
associated pathology are unclear. Here, we report the results of
histopathological examination of lungs of free-living wild mammals
from the south-west UK coupled with digestion of lung material in
potassium hydroxide followed by centrifugation and microscopic
examination for the presence of adiaspores. The combined results
showed that almost one-third (27/94, 28.7%) of animals examined had
evidence of infection with E. crescens. Attempts to culture E.
crescens from infected lungs were unsuccessful. However, E. crescens
could be confirmed as the causative agent by PCR amplification and
sequencing of DNA from adiaspores micro-dissected from animal lungs.
The prevalence of adiaspiromycosis was largely independent of animal
species or precise geography. Adiaspore burdens in most animals were
low, consistent with transient exposure to E. crescens. However,
burdens in several animals suggested heavy or repeated exposures to E.
crescens, and were considered sufficient to have significantly
impaired respiratory function. Finally, since E. crescens is
apparently widespread in UK mammals and the first UK human case of
adiaspiromycosis was reported recently, we present data obtained using
a previous isolate of E. crescens demonstrating that both the mycelial
and adiaspore phases of the organism are susceptible to amphotericin
B, voriconazole, itraconazole and caspofungin.
PMID: 19533414
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
------------------------------------
Yahoo! Groups Links
<*> To visit your group on the web, go to:
http://groups.yahoo.com/group/ferrethealth/
<*> Your email settings:
Individual Email | Traditional
<*> To change settings online go to:
http://groups.yahoo.com/group/ferrethealth/join
(Yahoo! ID required)
<*> To change settings via email:
mailto:ferrethealth-digest@yahoogroups.com
mailto:ferrethealth-fullfeatured@yahoogroups.com
<*> To unsubscribe from this group, send an email to:
ferrethealth-unsubscribe@yahoogroups.com
<*> Your use of Yahoo! Groups is subject to:
http://docs.yahoo.com/info/terms/