From:
"Joan Clague"
Date: 2009-06-24 15:36:13 UTC
Subject: [ferrethealth] Re: abstracts Including a new vaccine approach being studied for CDV
To: ferrethealth@yahoogroups.com
This brings back an old memory of a previous measles vaccine put on the market about 30-40 years ago which had unintended and disastrous consequences for many breeders who used it. It was developed to protect young pups from distemper until their immune systems were well enough developed to give the regular series of distemper vaccine. As was discovered several months later, after a number of pups who had received the measles vaccine at 6 weeks and then the series of distemper shots came down with distemper, the measles vaccine had triggered an immunity to the vaccine but not to distemper.
I was one of the few breeders who didn't use it, as I followed my vet's advice. He told me to let the other breeders use anything new and wait at least 2 years before using it on my dogs, as that would give time for the side effects and unintended consequences which didn't show up in the trials to present themselves.
Joan
[30 or 40 years ago the techniques would have been vastly different.
The chimeric approaches that exist today would have seemed like
science fiction then, but certainly long term study on a large enough
population is called for as are reaction rates. -- Mod
--- In ferrethealth@yahoogroups.com, Sukie Crandall <sukie@...> wrote:
>
> http://www.ncbi.nlm.nih.gov/pubmed/19540272
>
> BEGIN QUOTE
> Vaccine. 2009 Jun 17. [Epub ahead of print]
> A chimeric measles virus with canine distemper envelope protects
> ferrets from lethal distemper challenge.
> Rouxel RN, Svitek N, von Messling V.
> INRS-Institut Armand-Frappier, University of Quebec, 531, boul. des
> Prairies, Laval, Quebec H7V 1B7, Canada.
>
> CDV infects a broad range of carnivores, and over the past decades it
> has caused outbreaks in a variety of wild carnivore populations. Since
> the currently available live-attenuated vaccine is not sufficiently
> safe in these highly susceptible species, we produced a chimeric virus
> combining the replication complex of the measles Moraten vaccine
> strain with the envelope of a recent CDV wild type isolate. The
> resulting virus did not cause disease or immunosuppression in ferrets
> and conferred protection from challenge with a lethal wild type
> strain, demonstrating its potential value for wildlife conservation
> efforts.
>
> PMID: 19540272
>
> END QUOTE
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