From:
Sukie Crandall
Date: 2009-07-02 23:01:29 UTC
Subject: [ferrethealth] pop press article on swine flu behavior in ferrets
To: fhl <ferrethealth@yahoogroups.com>, Ferret Mailing List <ferret-l@LISTSERV.FERRETMAILINGLIST.ORG>
I do not know how accurate it is.
http://www.bloomberg.com/apps/news?pid=3D20601124&sid=3DabAA7cQlO4Nc
According to the article when ferret actually get swine flu it has the=20
potential to more easily get deeply into the lungs.
It says that findings conflict on how readily ferrets can catch swine=20
flu, though. I have not encountered the more recent studies but till=20
now ferrets have not seemed terribly susceptible to swine flu types of=20
influenza (which agrees with CDC findings), though they say another=20
recent study does not find them any less susceptible than with other=20
influenza types they get.
Abstracts of articles referenced for the story:
http://www.sciencemag.org/cgi/content/abstract/1177238
Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza=20
Viruses in Ferrets and MiceTaronna R. Maines 1, Akila Jayaraman 2,=20
Jessica A. Belser 3, Debra A. Wadford 1, Claudia Pappas 1,Hui Zeng 1,=20
Kortney M. Gustin 1, Melissa B. Pearce 1, Karthik Viswanathan 2,=20
Zachary H. Shriver 2,Rahul Raman 2, Nancy J. Cox 1, Ram Sasisekharan=20
2, Jacqueline M. Katz 1, Terrence M. Tumpey 1*
1 Influenza Division, National Center for Immunization and Respiratory=20
Diseases, Centers for Disease Control and Prevention, Atlanta, GA=20
30333, USA.
2 Harvard-MIT Division of Health Sciences and Technology and Koch=20
Institute for Integrative Cancer Research, Department of Biological=20
Engineering, Massachusetts Institute of Technology, E25-519,=20
Cambridge, MA 02139, USA.
3 Influenza Division, National Center for Immunization and Respiratory=20
Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia=20
30333, USA.
Recent reports of mild to severe influenza-like illness in humans=20
caused by a novel swine-origin 2009 A(H1N1) influenza virus underscore=20
the need to better understand the pathogenesis and transmission of=20
these viruses in mammals. Here, selected 2009 A(H1N1) isolates were=20
assessed for their ability to cause disease in mice and ferrets, and=20
compared with a contemporary seasonal H1N1 virus for their ability to=20
transmit by respiratory droplets to na=EFve ferrets. In contrast to=20
seasonal influenza H1N1 virus, 2009 A(H1N1) viruses caused increased=20
morbidity, replicated to higher titers in lung tissue, and were=20
recovered from the intestinal tract of intranasally inoculated=20
ferrets. The 2009 A(H1N1) viruses exhibited less efficient respiratory=20
droplet transmission in ferrets in comparison to the high-
transmissible phenotype of a seasonal H1N1 virus. Transmission of the=20
2009 A(H1N1) viruses was further corroborated by characterizing the=20
binding specificity of the viral hemagglutinin to the sialylated=20
glycan receptors (in the human host) using dose-dependent direct=20
receptor binding and human lung tissue binding assays.
http://www.sciencemag.org/cgi/content/abstract/1177127
Pathogenesis and Transmission of Swine-Origin 2009 A(H1N1) Influenza=20
Virus in FerretsVincent J. Munster 1
----------
, Emmie de Wit 1
----------
, Judith M. A. van den Brand 1, Sander Herfst 1,Eefje J. A. Schrauwen=20
1, Theo M. Bestebroer 1, David van de Vijver 1, Charles A. Boucher=20
1,Marion Koopmans 2, Guus F. Rimmelzwaan 1, Thijs Kuiken 1, Albert D.=20
M. E. Osterhaus 1,Ron. A. M. Fouchier 1*
1 National Influenza Center and Department of Virology, Erasmus=20
Medical Center, Rotterdam, the Netherlands.
2 National Influenza Center and Department of Virology, Erasmus=20
Medical Center, Rotterdam, the Netherlands.; National Institute for=20
Public Health and the Environment, Bilthoven, the Netherlands.
----------
These authors contributed equally to this work.
The swine-origin influenza A(H1N1) virus that has emerged in humans in=20
early 2009 has raised concerns about pandemic developments. In a=20
ferret pathogenesis and transmission model, the 2009 A(H1N1) virus was=20
found to be more pathogenic than a seasonal A(H1N1) virus, with more=20
extensive virus replication occurring in the respiratory tract.=20
Replication of seasonal A(H1N1) virus was confined to the nasal cavity=20
of ferrets, but 2009 A(H1N1) also replicated in the trachea, bronchi,=20
and bronchioles. Virus shedding was more abundant from the upper=20
respiratory tract for 2009 A(H1N1) virus by comparison with seasonal=20
virus, and transmission via aerosol or respiratory droplets was=20
equally efficient. These data suggest that the 2009 A(H1N1) virus has=20
the ability to persist in the human population, potentially with more=20
severe clinical consequences.
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
[Non-text portions of this message have been removed]
------------------------------------
Yahoo! Groups Links
<*> To visit your group on the web, go to:
http://groups.yahoo.com/group/ferrethealth/
<*> Your email settings:
Individual Email | Traditional
<*> To change settings online go to:
http://groups.yahoo.com/group/ferrethealth/join
(Yahoo! ID required)
<*> To change settings via email:
mailto:ferrethealth-digest@yahoogroups.com
mailto:ferrethealth-fullfeatured@yahoogroups.com
<*> To unsubscribe from this group, send an email to:
ferrethealth-unsubscribe@yahoogroups.com
<*> Your use of Yahoo! Groups is subject to:
http://docs.yahoo.com/info/terms/