From:
Sukie Crandall
Date: 2009-07-04 20:58:32 UTC
Subject: [ferrethealth] abstracts
To: fhl <ferrethealth@yahoogroups.com>
> Science. 2009 Jul 3;325(5936):17.
> Ferrets Shed Light on New Virus's Severity and Spread.
> Enserink M.
[no abstract]
> PMID: 19574354 [PubMed - as supplied by publisher]
>
----
> Science. 2009 Jul 2. [Epub ahead of print]
> Pathogenesis and Transmission of Swine-Origin 2009 A(H1N1) Influenza=20
> Virus in Ferrets.
> Munster VJ, de Wit E, van den Brand JM, Herfst S, Schrauwen EJ,=20
> Bestebroer TM, van de Vijver D,Boucher CA, Koopmans M, Rimmelzwaan=20
> GF, Kuiken T, Osterhaus AD, Fouchier RA.
> National Influenza Center and Department of Virology, Erasmus=20
> Medical Center, Rotterdam, the Netherlands.
>
> The swine-origin influenza A(H1N1) virus that has emerged in humans=20
> in early 2009 has raised concerns about pandemic developments. In a=20
> ferret pathogenesis and transmission model, the 2009 A(H1N1) virus=20
> was found to be more pathogenic than a seasonal A(H1N1) virus, with=20
> more extensive virus replication occurring in the respiratory tract.=20
> Replication of seasonal A(H1N1) virus was confined to the nasal=20
> cavity of ferrets, but 2009 A(H1N1) also replicated in the trachea,=20
> bronchi, and bronchioles. Virus shedding was more abundant from the=20
> upper respiratory tract for 2009 A(H1N1) virus by comparison with=20
> seasonal virus, and transmission via aerosol or respiratory droplets=20
> was equally efficient. These data suggest that the 2009 A(H1N1)=20
> virus has the ability to persist in the human population,=20
> potentially with more severe clinical consequences.
>
> PMID: 19574348
>
----
> Science. 2009 Jul 2. [Epub ahead of print]
> Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza=20
> Viruses in Ferrets and Mice.
> Maines TR, Jayaraman A, Belser JA, Wadford DA, Pappas C, Zeng H,=20
> Gustin KM, Pearce MB, Viswanathan K, Shriver ZH, Raman R, Cox NJ,=20
> Sasisekharan R, Katz JM, Tumpey TM.
> Influenza Division, National Center for Immunization and Respiratory=20
> Diseases, Centers for Disease Control and Prevention, Atlanta, GA=20
> 30333, USA.
>
> Recent reports of mild to severe influenza-like illness in humans=20
> caused by a novel swine-origin 2009 A(H1N1) influenza virus=20
> underscore the need to better understand the pathogenesis and=20
> transmission of these viruses in mammals. Here, selected 2009=20
> A(H1N1) isolates were assessed for their ability to cause disease in=20
> mice and ferrets, and compared with a contemporary seasonal H1N1=20
> virus for their ability to transmit by respiratory droplets to na=EFve =
> ferrets. In contrast to seasonal influenza H1N1 virus, 2009 A(H1N1)=20
> viruses caused increased morbidity, replicated to higher titers in=20
> lung tissue, and were recovered from the intestinal tract of=20
> intranasally inoculated ferrets. The 2009 A(H1N1) viruses exhibited=20
> less efficient respiratory droplet transmission in ferrets in=20
> comparison to the high-transmissible phenotype of a seasonal H1N1=20
> virus. Transmission of the 2009 A(H1N1) viruses was further=20
> corroborated by characterizing the binding specificity of the viral=20
> hemagglutinin to the sialylated glycan receptors (in the human host)=20
> using dose-dependent direct receptor binding and human lung tissue=20
> binding assays.
>
> PMID: 19574347
>
----
[I think the one below is one I've referred to a month or two ago when=20
something like 8% of the 1,000 ferrets were infected. See:
http://ferrethealth.org/archive/FHL8818 ]
> J Vet Diagn Invest. 2009 Jul;21(4):527-30. Links
> Naturally occurring influenza infection in a ferret (Mustela=20
> putorius furo) colony.
> Patterson AR, Cooper VL, Yoon KJ, Janke BH, Gauger PC.
> 1653 Veterinary Medicine Building, 1600 South 16th Street, Ames, IA=20
> 50010.
>
> Tissue samples from 2 juvenile ferrets (Mustela putorius furo) from=20
> a colony that was undergoing an outbreak of respiratory disease were=20
> submitted to the Iowa State University Veterinary Diagnostic=20
> Laboratory. Microscopic examination of lung samples revealed=20
> bronchointerstitial pneumonia with necrotizing bronchiolitis.=20
> Influenza A virus was detected in sections of formalin-fixed lung by=20
> immunohistochemistry and reverse transcription polymerase chain=20
> reaction assay. A field investigation of the premises and analysis=20
> of additional samples led to the confirmation and characterization=20
> of an influenza virus with high homology to contemporary reassortant=20
> H1N1 swine influenza viruses. Although ferrets have been used=20
> extensively to research the virulence and transmissibility of avian,=20
> human, and swine influenza virus strains, no published information=20
> exists on naturally occurring outbreaks of swine influenza in ferrets.
>
> PMID: 19564504
>
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
------------------------------------
Yahoo! Groups Links
<*> To visit your group on the web, go to:
http://groups.yahoo.com/group/ferrethealth/
<*> Your email settings:
Individual Email | Traditional
<*> To change settings online go to:
http://groups.yahoo.com/group/ferrethealth/join
(Yahoo! ID required)
<*> To change settings via email:
mailto:ferrethealth-digest@yahoogroups.com
mailto:ferrethealth-fullfeatured@yahoogroups.com
<*> To unsubscribe from this group, send an email to:
ferrethealth-unsubscribe@yahoogroups.com
<*> Your use of Yahoo! Groups is subject to:
http://docs.yahoo.com/info/terms/