From:
"Tressie"
Date: 2009-07-14 15:05:54 UTC
Subject: [ferrethealth] Re: Deslorelin Implant side effects?
To: ferrethealth@yahoogroups.com
Here's an abstract for another paper:
The Treatment of Adrenal Cortical Disease in Ferrets with 4.7-mg Deslorelin=
Acetate Implants
This article is not included in your organization's subscription. However, =
you may be able to access this article under your organization's agreement =
with Elsevier.
Robert A. Wagner VMDa, , , Mark R. Finkler DVMb, Kellie A. Fecteau PhDc and=
Tim E. Trigg PhDd
aDivision of Laboratory Animal Resources, Pittsburgh, PA, USA
bRoanoke Animal Hospital, Roanoke, VA USA
cDepartment of Comparative Medicine (Clinical Endocrinology Service), Colle=
ge of Veterinary Medicine, The University of Tennessee, Knoxville, TN USA
dPeptech Animal Health, Macquarie Park, NSW, Australia
Available online 25 June 2009.
Abstract
Thirty pet ferrets with adrenocortical disease (ACD) of varying severity an=
d duration were evaluated for response to a single administration of a slow=
release 4.7 mg deslorelin acetate implant. Clinical response to deslorelin=
was monitored via a physical examination performed every 3 to 4 months. Ad=
renal ultrasound measurements were taken every 3-4 months until clinical re=
lapse. At clinical relapse, duration of symptom suppression and adrenal siz=
e and growth were determined. Administration of a single 4.7 mg implant of =
deslorelin acetate resulted in significant decreases in the clinical signs =
and hormonal concentrations associated with ACD. Within 14 days post-implan=
t, vulvar swelling, pruritus, sexual behaviors and aggression decreased or =
disappeared. Hair re-growth was evident by 4-6 weeks post implant. Within t=
wo months post deslorelin implant, plasma concentrations of steroid hormone=
s decreased: mean estradiol concentration decreased 28%; 17-hydroxyprogeste=
rone levels decreased 89% and androstenedione levels decreased 88%. The res=
ponse to a single 4.7 mg implant of deslorelin acetate was transitory. The =
mean =B1 SD time to recurrence of clinical signs was 17.6 =B1 5.0 months (r=
ange, 8.0-30.0 months). Repeated ultrasound measurements revealed no statis=
tical difference in size of the adrenals (right or left) before, during the=
months of deslorelin implant and at clinical relapse. Slow release 4.7 mg =
deslorelin implants can effectively be used to temporarily eliminate the cl=
inical signs and reduce steroid hormone concentrations in ferrets with ACD.=
This dose of deslorelin does appear to influence adrenal tumor growth caus=
ing a decrease in adrenal size in some ferrets, and mild enlargement of adr=
enal glands in most ferrets with 2 of 30 implanted animals developing large=
tumors before clinical relapse. The long-term effect of treatment with des=
lorelin on adrenal tumor pathology requires additional investigation. At th=
is time, surgical removal of the adrenal tumor remains the only curative tr=
eatment; however, 4.7 mg deslorelin implants are useful in the long-term ma=
nagement of ACD hormone-induced sequelae and may be as effective as surgica=
l management.
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