From:
Sukie Crandall
Date: 2009-07-26 19:20:00 UTC
Subject: [ferrethealth] abstract: same genus but different species
To: fhl <ferrethealth@yahoogroups.com>
Still may prove of interest since ferrets are already vulnerable to
squamous cell carcinoma in that location so knowing what might
worsen risk rates might be helpful:
http://www.ncbi.nlm.nih.gov/pubmed/19621204
Arch Environ Contam Toxicol. 2009 Jul 21. [Epub ahead of print]
Histological Lesions in Mink Jaws Are a Highly Sensitive Biomarker of
Effect After Exposure to TCDD-Like Chemicals: Field and Literature-
Based Confirmations.
Haynes JM, Wellman ST, Beckett KJ, Pagano JJ, Fitzgerald SD,Bursian SJ.
Department of Environmental Science and Biology, The College at
Brockport, State University of New York, Brockport, NY, 14420, USA, jhaynes@brockport.edu
.
The mink (Mustela vison) is one of the most sensitive mammals to
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-like chemicals. By
literature review we established that a histological lesion of the jaw
bone of mink, evidenced by squamous epithelial hyperplasia in the
gingival tissue that forms nests or cords that infiltrate the
periodontal ligament and alveolar bone causing osteolysis of the
mandible and maxilla that could lead to squamous cell carcinoma, is
the most sensitive known biomarker of effect following exposure of
mink to TCDD-like chemicals. Lesions have been observed when total
TCDD toxic equivalents (TEQ: dioxins, furans, coplanar polychlorinated
biphenyls or PCBs) in liver exceed 40 ng/kg wet weight (ww) or when
total PCB exceeds 1698 ng/g ww. This is the second report of
histological evidence of this lesion in wild-caught mink, and it is
the first report of the lesion being grossly detectable in naturally
exposed mink. Some mink living near the south shore of Lake Ontario
(exposed to the lake's food web), but not inland mink (not exposed to
the lake's food web), accumulate more than 40 ng total TEQ/kg or 1698
ng total PCB/kg in liver. Because of its sensitivity, the jaw lesion
biomarker is very useful for assessing the health of wildlife
populations exposed to TCDD-like chemicals.
PMID: 19621204
Ferret:
http://www.afip.org/consultation/vetpath/ferrets/SCC/SCC.html
Related:
http://www.ncbi.nlm.nih.gov/pubmed/15779768
http://www.ncbi.nlm.nih.gov/pubmed/15669299
http://www.ncbi.nlm.nih.gov/pubmed/18435568
Perhaps a chemist or other knowledgeable individual on the FHL
may tell if there is an exposure risk for these in everyday household
living and if so then specifically from what. I am trying to recall if one
of these is shed from a type of flexible and clear plastic found in
beverage and water bottles, but can't recall and suspect that my
recollection on that score is very possibly wrong.
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
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