Message Number: FHL9762 | New FHL Archives Search
From: Sukie Crandall
Date: 2009-08-30 00:14:36 UTC
Subject: [ferrethealth] Abstract: Campylobacter jejuni
To: fhl <>

> Comp Med. 2009 Aug;59(4):363-71.
> Immune response to and histopathology of Campylobacter jejuni
> infection in ferrets (Mustela putorius furo).
> Nemelka KW, Brown AW, Wallace SM, Jones E, Asher LV, Pattarini D,
> Applebee L, Gilliland TC Jr, Guerry P, Baqar S.
> Division of Veterinary Medicine, Naval Medical Research Center,
> Silver Spring, Maryland, USA.
> Campylobacter jejuni is 1 of the most common enteric bacterial
> pathogens worldwide. The mechanisms of pathogenesis remain obscure,
> in part because of limitations of small animal models. Young ferrets
> develop diarrhea when fed C. jejuni, but their pathology and the
> immune response after infection have not been examined in detail. In
> the present study, we examined the pathogenesis of C. jejuni CG8421
> and associated immune responses in ferrets. After oral infection
> with C. jejuni CG8421, 86.7% of the animals developed diarrhea and
> inflammatory responses that were similar to those seen in human
> infection. Pronounced histopathologic changes in the colonic mucosa
> of infected animals were observed during the acute phase (days 1
> through 3) of infection. Electron micrographs of colonic epithelium
> revealed disruption of the villi and internalized bacteria that were
> not within membrane vacuoles. During the acute phase, C. jejuni was
> isolated from the livers of 7 of 9 (78%) animals, and bacteria were
> visualized immunohistochemically in the livers from 5 of the 7
> animals (71%) from which C. jejuni was isolated. A vigorous systemic
> and mucosal immune response to Campylobacter antigens was elicited
> after infection of ferrets. The data presented contribute to the
> current knowledge of the pathogenicity of and immunologic response
> to C. jejuni CG8421 in ferrets and better understanding of this model.
> PMID: 19712577

Sukie (not a vet)

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