From:
Joan Evancic-Sheer
Date: 2009-08-30 14:22:56 UTC
Subject: [ferrethealth] Pasturella
To: ferrethealth@yahoogroups.com
I hadn't the time for extensive search,
=C2=A0but this
Pub Med Abstract explains it's common existence:
http://www.ncbi.nlm.nih.gov/pubmed/8891937?ordinalpos=3D2&itool=3DEntrezSys=
tem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RV=
DocSum
Fischer RG, Edwardsson S, Klinge B, Attstr=C3=B6m R.
Department of Periodontology, Lund University, Malm=C3=B6, Sweden.
The effect of cyclosporin-A (CyA) on the dentogingival flora of ferrets wit=
h healthy and experimentally induced periodontal breakdown was studied. Fiv=
e animals were given 10 mg/kg/d CyA. At the start of the experiments (day 0=
), ligatures were placed around 4 teeth in the right upper and lower jaws; =
corresponding contralateral teeth on the left side served as control. On da=
ys 0 and 28 (end of the experiment), microbiological samples were collected=
from the gingival sulcus of the experimental and the control teeth and fro=
m closely located gingival mucosa membrane. The samples were subjected to v=
iable counts and to darkfield microscopic analyses. On day 0, facultative a=
naerobic rods, mainly Pasteurella spp, Alcaligenes spp, Corynebacterium spp=
. and Rothia spp dominated in the viable counts. No anaerobic bacteria were=
detected in the viable counts. On day 28 spirochetes increased in the expe=
rimental gingival sulcus samples and anaerobic bacteria appeared in most of=
the samples and constituted 40-60% of the total cultivable flora; Fusobact=
erium necrophorum and Eubacterium spp. predominated in the samples from the=
experimental sites. The results of the present study were compared with th=
ose of our previous investigation of ferrets not medicated with cyclosporin=
but also subject to experimental ligature periodontitis. Eubacterium spp. =
were absent in the animals not treated with cyclosporin, while this species=
was frequently present in the immunosuppressed ferrets. The results indica=
te that the presence of the large numbers of gram negative rods and of anae=
robic bacteria may have enhanced the inflammatory process and further provo=
ked the gingival overgrowth observed.
J.Scheer
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