From:
Sukie Crandall
Date: 2009-09-20 21:10:19 UTC
Subject: [ferrethealth] abstract Nipah
To: fhl <ferrethealth@yahoogroups.com>
> J Virol. 2009 Sep 16. [Epub ahead of print]
> Chloroquine administration does not prevent Nipah virus infection
> and disease in ferrets.
> Pallister J, Middleton D, Crameri G, Yamada M, Klein R, Hancock TJ,
> Foord A, Shiell B, Michalski W,Broder CC, Wang LF.
> CSIRO Livestock Industries, Australian Animal Health Laboratory,
> Geelong, Victoria 3220, Australia; Department of Microbiology and
> Immunology, Uniformed Services University, Bethesda, Maryland 20814,
> USA.
>
> Hendra virus and Nipah virus, two zoonotic paramyxoviruses in the
> genus Henipavirus, have recently emerged and continue to cause
> sporadic disease outbreaks in humans and animals. Mortality rates of
> up to 75% have been reported in humans, but there are presently no
> clinically licensed therapeutics for treating henipavirus-induced
> disease. A recent report indicated that chloroquine, used in malaria
> therapy for over 70 years, prevented infection with Nipah virus in
> vitro. Chloroquine was assessed using a ferret model of lethal Nipah
> virus infection and found to be ineffective against Nipah virus
> infection in vivo.
>
> PMID: 19759137
>
Full Article:
http://jvi.asm.org/cgi/reprint/JVI.01847-09v1?view=long&pmid=19759137
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
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