From:
Sukie Crandall
Date: 2009-09-26 18:34:04 UTC
Subject: [ferrethealth] deslorelin/Suprelorlin: looks like good news
To: fhl <ferrethealth@yahoogroups.com>, Ferret Mailing List <ferret-l@LISTSERV.FERRETMAILINGLIST.ORG>
In early August the CVM portion of the FDA and another portion=20
realized that they had a conflict over how much approval the=20
deslorelin implant imports needed. During that time I heard from some=20
people, including another FHL moderator that importing had gotten=20
harder and more limited.
Today I heard from another FHL Moderator that getting the implants is=20
now easier than ever according to her vet. It looks currently like=20
the prevailing line of thought goes along with the CVM portion of the=20
FDA that I heard from which felt that the implant technology should=20
not need a separate approval because deslorelin already had the 1998=20
approval for
> NADA 141-044 original approval
> Sponsor: Peptech Animal Health Pty, Limited
> Generic Name: Deslorelin Acetate
> Trade Name: Ovuplant (tm)
> Indications for Use: For inducing ovulation within 48 hours in estrous
> mares with an ovarian follicle greater than 30 mm in diameter.
> Date of Approval: June 18, 1998
>
> Please see
> http://www.accessdata.fda.gov/scripts/animaldrugsatfda/details.cfm?dn=3D1=
4
> 1-044 for the entry in the Animal Drugs @ FDA database.
I do NOT know if the Peptech implant technology has a separate=20
approval in any other drug use. If it does that would have speeded=20
things along, too.
Right now it looks like the treating vets just need to get in touch=20
with Peptech:
Peptech Animal Health Pty. Limited
19 - 25 Khartoum Rd.
Macquarie Par, New South Wales, 2113
Australia
http://www.peptech.com/HTML/Animal_Health/Animal_Health.html
or it might help to contact the European distributor:
http://ferrethealth.org/archive/FHL9888
Tony includes:
> For those in the US who may have approval to import suprelorin.
> These implants are also available from Virbac the European licence=20
> holder. They have offices in most European countries. the UK address=20
> of which is :-
>
> Virbac Limited
>
> Woolpit Business Park
> Windmill Avenue
> Woolpit
> Bury St Edmunds
> Suffolk
> IP30 9UP
> Telephone:
> 01359 243243
> Fax:
> 01359 243200
> Website:
> www.virbac.co.uk
>
> A direct link to the correct product is :-
>
> http://www.noahcompendium.co.uk/Virbac_Limited/Suprelorin_4_7_mg_implant_=
for_dogs/-48966.html
>
> The current price in the UK is 49 UK pounds =3D 78 US for pack of 2x=20
> 4.7 mg implants
Be sure to ask for ones that do not have a close expiration date since=20
in ferrets the length of time that deslorelin/Suprelorin (Use the dog=20
implant, I think, but check me on that.) may work in ferrets with=20
adrenal disease is something like 8 months to 18 months in studies.
Temporary chemical castration:
http://www.ncbi.nlm.nih.gov/pubmed/18439664
> Theriogenology. 2008 Jul 15;70(2):161-7. Epub 2008 Apr 25.
> Use of a gonadotropin releasing hormone agonist implant as an=20
> alternative for surgical castration in male ferrets (Mustela=20
> putorius furo).
> Schoemaker NJ, van Deijk R, Muijlaert B, Kik MJ, Kuijten AM, de Jong=20
> FH, Trigg TE, Kruitwagen CL, Mol JA.
> Department of Clinical Sciences of Companion Animals, Faculty of=20
> Veterinary Medicine, Utrecht University, The Netherlands. N.J.Schoemaker@=
uu.nl
>
> Surgical castration in ferrets has been implicated as an etiological=20
> factor in the development of hyperadrenocorticism in this species=20
> due to a castration-related increase in plasma gonadotropins. In=20
> search for a suitable alternative, the effect of treatment with the=20
> depot GnRH-agonist implant, deslorelin, on plasma testosterone=20
> concentrations and concurrent testes size, spermatogenesis, and the=20
> typical musky odor of intact male ferrets was investigated. Twenty-
> one male ferrets, equally divided into three groups, were either=20
> surgically castrated, received a slow release deslorelin implant or=20
> received a placebo implant. Plasma FSH and testosterone=20
> concentrations, testis size and spermatogenesis were all suppressed=20
> after the use of the deslorelin implant. The musky odor in the=20
> ferrets which had received a deslorelin implant was less compared to=20
> the ferrets which were either surgically castrated or had received a=20
> placebo implant. These results indicate that the deslorelin implant=20
> effectively prevents reproduction and the musky odor of intact male=20
> ferrets and is therefore considered a suitable alternative for=20
> surgical castration in these animals.
>
> PMID: 1843966
>
Adrenal disease:
http://www.ncbi.nlm.nih.gov/pubmed/15934621
> Am J Vet Res. 2005 May;66(5):910-4.Links
> Clinical and endocrine responses to treatment with deslorelin=20
> acetate implants in ferrets with adrenocortical disease.
> Wagner RA, Pich=E9 CA, J=F6chle W, Oliver JW.
> Division of Laboratory Animal Resources, 3500 Terrace St, S1049 BST,=20
> University of Pittsburgh, Pittsburgh, PA 15261, USA.
>
> OBJECTIVE: To evaluate the clinical and endocrine responses of=20
> ferrets with adrenocortical disease (ACD) to treatment with a slow-
> release implant of deslorelin acetate. ANIMALS: 15 ferrets with ACD.=20
> PROCEDURE: Ferrets were treated SC with a single slow-release, 3-mg=20
> implant of deslorelin acetate. Plasma estradiol, androstenedione,=20
> and 17-hydroxyprogesterone concentrations were measured before and=20
> after treatment and at relapse of clinical signs; at that time, the=20
> adrenal glands were grossly or ultrasonographically measured and=20
> affected glands that were surgically removed were examined=20
> histologically. RESULTS: Compared with findings before deslorelin=20
> treatment, vulvar swelling, pruritus, sexual behaviors, and=20
> aggression were significantly decreased or eliminated within 14 days=20
> of implantation; hair regrowth was evident 4 to 6 weeks after=20
> treatment. Within 1 month of treatment, plasma hormone=20
> concentrations significantly decreased and remained decreased until=20
> clinical relapse. Mean time to recurrence of clinical signs was 13.7=20
> +/- 3.5 months (range, 8.5 to 20.5 months). In 5 ferrets, large=20
> palpable tumors developed within 2 months of clinical relapse; 3 of=20
> these ferrets were euthanatized because of adrenal gland tumor=20
> metastasis to the liver or tumor necrosis. CONCLUSIONS AND CLINICAL=20
> RELEVANCE: In ferrets with ACD, a slow-release deslorelin implant=20
> appears promising as a treatment to temporarily eliminate clinical=20
> signs and decrease plasma steroid hormone concentrations. Deslorelin=20
> may not decrease adrenal tumor growth in some treated ferrets.=20
> Deslorelin implants may be useful in the long-term management of=20
> hormone-induced sequelae in ferrets with ACD and in treatment of=20
> animals that are considered at surgical or anesthetic risk.
>
> PMID: 15934621
>
and there are other studies in the Netherlands, the U.S., and either=20
Hungary or Poland, but my profuse apologies because I don't recall=20
which. (Right now I am under a lot of strain with a very ill=20
hospitalized niece so my memory is not totally functional from=20
stress. Thank goodness the other family members who were very ill are=20
now doing okay. It's been one person after another this year as well=20
as sick elder ferrets and Whizbang departed, but mostly things have=20
worked out okay...)
Anyway, this medication is related to Lupron, but longer lasting and=20
for those countries where it is easily gotten it is cheaper and may=20
well be cheaper for here, too, even with shipping.
According to Dr. Jerry Murray it can be used along with Melatonin=20
Implants
http://www.melatek.net/
Since this class of meds and melatonin work in different ways there is=20
better effect by using both than either alone.
http://ferrethealth.org/archive/FHL5827
http://ferrethealth.org/archive/FHL9686
I can't find the post I am looking for and don't have time to look=20
further so this will have to suffice and people can look further in=20
the separate FHL Archives for themselves.
Sukie (not a vet) (and glad about news just now received by Steve that=20
a friend is on the cover of a major horror movie magazine)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
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