From:
Sukie Crandall
Date: 2010-01-07 16:22:21 UTC
Subject: [ferrethealth] influenza treatment abstract
To: fhl <ferrethealth@yahoogroups.com>
> Antimicrob Agents Chemother. 2010 Jan 4. [Epub ahead of print]
> CS-8958 (laninamivir prodrug), a long-acting neuraminidase
> inhibitor, shows superior anti-influenza virus activity after a
> single administration.
> Kubo S, Tomozawa T, Kakuta M, Tokumitsu A, Yamashita M.
> Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd.,
> 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710, Japan.
> For the treatment and prophylaxis of influenza, two neuraminidase
> (NA) inhibitors, zanamivir (Relenza(TM)) and oseltamivir phosphate
> (Tamiflu(TM)), have been licensed. We have reported on laninamivir
> (code name, R-125489), a novel neuraminidase inhibitor, and have
> discovered that CS-8958, laninamivir prodrug, worked as a long
> acting neuraminidase inhibitor in a mouse influenza virus infection
> model when it was intranasally administered. In this paper, CS-8958
> administered just once 7 days before infection showed significant
> efficacy in vivo. Then, the efficacy by a single administration of
> CS-8958 after viral infection was compared with that by repeated
> administrations of oseltamivir phosphate or zanamivir in mice and
> ferrets and CS-8958 showed superior or similar efficacy to the two
> licensed NA inhibitors. CS-8958 also significantly reduced the virus
> titers of an oseltamivir-resistant H1N1 virus with a neuraminidase
> H274Y substitution in a mouse infection model. These results suggest
> that, since CS-8958 is characteristically long lasting in the lungs,
> it may be ideal for the prophylaxis and treatment of influenza.
> PMID: 20047917
FULL TEXT:
http://aac.asm.org/cgi/reprint/AAC.01311-09v1?view=long&pmid=20047917
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
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