From:
"Kevin Farlee"
Date: 2010-01-16 17:40:51 UTC
Subject: [ferrethealth] Re:Dissolving Meds
To: <ferrethealth@yahoogroups.com>
[BEGIN QUOTE FROM ORIGINAL POST]
Recently I've had a foster that was directed to give 0.7mg Omeprazole daily
by the vet. I use this med, dissolved in water, all the time, for years,
with much success! However, after a week, the ferret was still grinding it's
teeth, and not eating kibble, and being handfed AD watered down.
I reviewed the protocol with the foster mom, and found out she was emptying
the capsule into Ferretone, no water, and administering. I asked that she
first dissolve in water, flavor, then give. This evening I get a good report
that finally the ferret has stop grinding, and is eating on its own.
Coincidence? I'd like to know.
I've got a concern that some tablet and capsulated meds should first be
dissolved in water. My personal observation is that the med does not
dissolve in the Ferretone, but appears suspended.
[END QUOTE]
I agree with Barb and Sukie that it is critically important to know the
specifics of each medicine used, and what it can and cannot safely be mixed
with. This goes beyond the liquid used to dissolve/compound it, and also
means knowing which other drugs it will react badly with. If you don't
know, ask someone who does.
In this case however, I'd like to raise an alternate possibility as to what
may be going on:
There have been many studies documenting the fact that fats and oils can
trigger acid production in the ferret [1], [2].
In fact, the ferret was the laboratory model used when developing
famotidine/Pepcid, and straight oil was used to provoke the acid in order to
determine if the medication was effective.
That's not to say that any oil is harmful; obviously not every ferret who's
gotten a Ferretone treat has come down with an ulcer, but there IS a proven
relationship, and the dosages should be kept to a minimum.
In this case, it seems quite probable that in addition to the impact that
the Ferretone may have had on the Omeperazole, the Ferretone itself may have
been making the root problem worse on its own, counteracting the effect of
the medicine.
[1] Blackshaw LA, Staunton E, Dent J et al. Mechanisms of gastro-esophageal
reflux in the ferret. Neurogastroentero Motil 1998; 10(1):49-56
[2]Johnson-Delaney CA et al. The Ferret Gastrointestinal Tract and
Heliobacter mustelae Infection Vet Clin Exot Anim 8 (2005) 197-212
Kevin Farlee
[Non-text portions of this message have been removed]
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